肺纤方对博莱霉素肺纤维化大鼠血小板衍生因子、内皮素、血栓素-2的影响

目的 探讨活血化瘀药物肺纤方抑制肺间质纤维化大鼠肺组织血管生成和重构的作用机理.方法 气管内注入博莱霉素制造大鼠肺纤维化模型,造模后14、28、45 d检测模型组、假手术组、肺纤方组、泼尼松组血清中的血小板衍生因子、内皮素、血栓素.结果 肺纤方能够显著降低血清中的血小板衍生因子、内皮素、血栓素.结论 肺纤方抗肺纤维化的作用机理,可能与抑制肺间质纤维化大鼠肺组织血管生成和重构有关.

Influences of Feixian Formula on PDGF, ET and TXB-2 in rats with pulmonary interstitial fibrosis induced by bleomycin

Objective To investigate the effect of Feixian Formula (with effects of activating blood circulation and resolving stasis), and mechanism of inhibiting lung vascular genesis and remodeling in rats with pulmonary interstitial fibrosis. Method The rat model of pulmonary interstitial fibrosis was established with intratracheal injection of bleomycin. On the 14th, 28th and 45th day after the establishment of the model the serum levels of platelet-derived growth factor (PDGF), endothelin (ET) and thromboxane (TXB-2) were detected in the model group, sham-operation group, Feixian Formula group and prednisone group respectively. Result Feixian Formula decreased significantly the serum levels of PDGF, ET and TXB-2. Conclusion The mechanism of antifibrosis of Feixian Formula may be related to that it can inhibit the lung vascular genesis and remodeling in rats with pulmonary interstitial fibrosis.