韧带急性损伤与组织工程人工材料修复的生物相容性分析

摘要 背景：阐述组织工程人工材料在韧带修复过程中生物相容性的必要性与重要性。 方法：由第一作者应用计算机检索PubMed数据库与CNKI数据库中与韧带急性损伤治疗手段、材料学特点、生物相容性及其应用效果相关的文章。 结果：韧带急性损伤后的修复手段中传统疗法较为保守，大多以物理疗法为主，在损伤不太严重的情况下修复效果较好，但对较为严重的韧带断裂或撕裂很难起到良好的修复效果。运用组织工程人工材料对严重的韧带断裂或撕裂进行韧带重建会起到很好的修复效果。在运用组织工程人工材料重建韧带过程中，理想生物材料的选择必须重视其良好的生物相容性，其生物相容性的好坏直接决定着韧带修复的效果，可以说良好的生物相容性应是组织工程治疗手段过程中生物材料选择的基础和必要条件。 结论：随着组织工程人工材料研究的进步，在多样化的生物材料中，保证生物材料良好的生物相容性是选择理想材料的基础。

Biocompatibility of tissue engineered artificial materials for acute ligament injury repair

Abstract OBJECTIVE: To investigate the necessity and importance of the biocompatibility of tissue engineered artificial materials in ligament repair process. METHODS: A computer-based online search of PubMed database and CNKI database was performed by the first author, for articles related to acute ligament injury treatment, materials science characteristics, biocompatibility and application effect. RESULTS: The traditional therapy for the repair means of acute ligament injury is conservative, mainly physical therapy, the repair effect is good for mild injuries, but is ineffective for serious ligament rupture or tear. The use of tissue engineering artificial materials may play a repair role in the restoration of serious ligament rupture or tear. Selection of ideal biomaterials in tissue engineering ligament reconstruction should pay attention on its biocompatibility, which directly determines the ligament repair effect, good biocompatibility is the base and necessary condition for the choice of biomaterials in tissue engineering treatment. CONCLUSION: With the advances of tissue engineered artificial materials, a good biocompatibility of the biomaterials is a basis for a variety of biological materials.