Mid-gestation Down syndrome screening test and pregnancy outcome among unstimulated assisted-conception pregnancies |
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Authors: | Shulman Adrian Maymon Ron |
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Affiliation: | Sheba Medical Center, Tel Hashomer and the Sackler Faculty of Medicine, Tel Aviv University, Israel. |
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Abstract: | OBJECTIVES: Alteration of mid-gestation serum markers in assisted-conception pregnancies is believed to be attributable to ovarian superovulation treatment modalities. We compared alpha-fetoprotein (AFP), human chorionic gonadotrophin (hCG), and unconjugated estriol (uE(3)) in two groups of unstimulated assisted-conception pregnancies, that is, own-oocyte frozen embryos (own-FET) versus oocyte-donated (OD) embryos. METHODS: Forty-three OD-conceived and 31 own-FET-conceived singleton parturient women (aged 29 +/- 4 years and 31 +/- 4 years respectively, P < 0.05) were followed from embryo transfer throughout pregnancy. RESULTS: The daily pattern of first-trimester serum beta-hCG was similar in both groups. The OD group had only significantly increased AFP concentrations compared to the own-FET group (1.38 vs 0.99 median MoM respectively, P = 0.002). Although there were no chromosomal abnormalities and no fetal or neonatal deaths in either group, 12% OD women and 6.5% own-FET women were found screen-positive. Eight OD women and 11 FET women had an adverse obstetric outcome (P = NS). CONCLUSION: OD embryos are a unique clinical model for evaluating the uterine compartment and its contribution to mid-gestation serum marker secretion. |
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