| 顺铂、丝裂霉素及沙培林序贯胸腔注入治疗恶性胸腔积液20例疗效观察 |
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| 引用本文： | 吕丽丽,朱述阳,杨荣礼,周晓兵.顺铂、丝裂霉素及沙培林序贯胸腔注入治疗恶性胸腔积液20例疗效观察[J].哈尔滨医药,2008,28(1):19-20. |
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| 作者姓名： | 吕丽丽 朱述阳 杨荣礼 周晓兵 |
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| 作者单位： | 徐州医学院附属医院,江苏,徐州,221002 |
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| 摘 要： | 目的观察沙培林联合顺铂、丝裂霉素治疗恶性胸腔积液的临床疗效。方法将40例恶性胸水患者随机分为序贯治疗组20例和常规治疗组20例。两组患者在胸腔闭式引流放尽胸水后,序贯治疗组注入顺铂、丝裂霉素和沙培林,常规治疗组注入顺铂、丝裂霉素治疗。结果序贯治疗组完全有效(CR)9例,部分有效(PR)9例,总有效率90%,常规治疗组CR6例,PR 7例,总有效率65%,两组比较差异有显著性(P<0.05)。结论沙培林、顺铂和丝裂霉素序贯治疗恶性胸腔积液疗效好,毒副作用少,有较高临床应用价值。
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| 关 键 词： | 恶性胸腔积液 沙培林 顺铂 丝裂霉素 胸腔内化疗 |
| 文章编号： | 1001-8131（2008）01-0019-02 |
| 收稿时间： | 2007-11-14 |
| 修稿时间： | 2007年11月14 |
Clinical Observation on Treatment Efficacy of Malignant Pleural Effusion by the use of Integrative OK-432,Cisplatin and Mitomycin |
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| LV Lili,ZHU Shuyang,YANG Rongli,ZHOU Xiaobing.Clinical Observation on Treatment Efficacy of Malignant Pleural Effusion by the use of Integrative OK-432,Cisplatin and Mitomycin[J].harbin medical journal,2008,28(1):19-20. |
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| Authors: | LV Lili ZHU Shuyang YANG Rongli ZHOU Xiaobing |
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| Abstract: | Objective To observe the effects of OK-432 combined with cisplatin(DDP) and mitomycin(MMC) in the treatment of malignant hydrothorax.Methods Forty patients with malignant hydrothorax were randomly divided into the therapeutic group(OK-432 DDP MMC,20 patients) and the control group(DDP MMC,20 patients).After completely depleting malignant pleural effusion,the therapeutic group patients were slowly injected with OK-432 cisplatin mitomycin into the thoracic cavity and the control group were injected cisplatin mitomycin.Results The response rate of the therapeutic group was 90%(18/20) and the control group was 65%(13/20);P<0.05.Conclusion The therapeutic effect of OK-432 combining with cisplation and therapy is markedly effective for malignant pleural effusion,and the toxic reaction is lower.It has better clinical value. |
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| Keywords: | Malignant pleural effusion OK-432 cisplatin mitomycin hydrothorax |
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