进展期胃底贲门癌淋巴结清扫数目对预后的影响

目的探讨D2根治术中淋巴结清扫数目对进展期胃底贲门癌患者的预后和术后并发症发生率的影响。方法总结施行D2根治术的236例进展期胃底贲门癌患者的临床资料，将其清扫淋巴结的数目与术后5年患者的生存率及术后并发症发生率的关系进行分析。结果236例进展期胃底贲门癌患者术后5年生存率为37．5％。相同病期患者的术后5年生存率随着淋巴结清扫数目的增加而增高（P=0．0013）。Ⅱ期患者淋巴结清扫数目超过或等于20枚（P=0．0136）、Ⅲ期超过或等于25枚（P〈0．0001）、Ⅳ期超过或等于30枚（P=0．0002）、整组病例超过或等于15枚（P=0．0024）时生存率高，且差异具有统计学意义。本组术后并发症发生率为15．7％，淋巴结清扫的数目与术后并发症发生率的相关性无统计学意义（P=0．101）。结论进展期胃底贲门癌患者在施行D：根治术时，淋巴结清扫数目与患者预后呈正相关；合理的淋巴结清扫数目并不增加患者术后并发症发生率。

Impact of dissected lymph node number on the prognosis of advanced cancer of cardiac and stomach fundus]

OBJECTIVE: To investigate the impact of dissected lymph node number on the prognosis of patients with advanced cancer of cardia and stomach fundus. METHODS: Clinical data of 236 patients with advanced cancer of cardia and stomach fundus undergone D(2) radical resection were reviewed retrospectively. Five-year survival rate and post-operative complication rate were followed up and their relationships with dissected lymph node number were analyzed respectively. RESULTS: The 5-year survival rate of the entire cohort was 37.5%. Among those patients with the same stage, the more lymph nodes (LNs) resected, the better survival outcomes achieved(Log-rank trend test P=0.0013). A cut point analysis yielded the ability to detect the significant survival differences. The best long-term survival outcomes were observed with LN counts of more than 20 for stage II(P=0.0136), more than 25 for stage III(P<0.0001), more than 30 for stage IV(P=0.0002) or more than 15 for the entire cohort (P=0.0024), with greatest comparative discrepancies. The post-operative complication rate was 15.7% and was not significantly correlated with dissected lymph node number(P=0.101). CONCLUSIONS: The prognosis of patients with advanced cancer of cardia and stomach fundus is associated with the number of resected LNs when D(2) lymphadenectomy is carried out. Suitable increment of dissected lymph node number would not increase the post-operative complication rate.