Inhibition of angiogenesis and suppression of colorectal cancer metastatic to the liver using the <Emphasis Type="Italic">Sleeping Beauty</Emphasis> Transposon System期刊界 All Journals 搜尽天下杂志传播学术成果专业期刊搜索期刊信息化学术搜索

Inhibition of angiogenesis and suppression of colorectal cancer metastatic to the liver using the Sleeping Beauty Transposon System

Authors:	Lalitha R Belur Kelly M Podetz-Pedersen Brent S Sorenson Alice H Hsu Josh B Parker Cathy S Carlson Daniel A Saltzman S Ramakrishnan R Scott McIvor

Affiliation:	(1) Center for Genome Engineering, University of Minnesota, Minneapolis, MN 55455, USA;(2) Gene Therapy Program, Institute of Human Genetics, University of Minnesota, Minneapolis, MN 55455, USA;(3) Department of Genetics, Cell Biology and Development, University of Minnesota, Minneapolis, MN 55455, USA;(4) Department of Veterinary Population Medicine, University of Minnesota, St. Paul, MN 55108, USA;(5) Department of Surgery, University of Minnesota, Minnesota, MN 55455, USA;(6) Department of Pharmacology, University of Minnesota, Minnesota, MN 55455, USA

Abstract:	Background Metastatic colon cancer is one of the leading causes of cancer-related death worldwide, with disease progression and metastatic spread being closely associated with angiogenesis. We investigated whether an antiangiogenic gene transfer approach using the Sleeping Beauty (SB) transposon system could be used to inhibit growth of colorectal tumors metastatic to the liver.

Keywords:
本文献已被 PubMed SpringerLink 等数据库收录！