| 正交设计法在制备生物可吸收储存式多孔药物载体中的应用 |
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| 引用本文： | 潘振宇 万涛 吴忠杰. 正交设计法在制备生物可吸收储存式多孔药物载体中的应用[J]. 生物骨科材料与临床研究, 2011, 8(1): 8-11. DOI: 10.3969/j.issn.1672-5972.2011.01.003 |
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| 作者姓名： | 潘振宇 万涛 吴忠杰 |
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| 作者单位： | 1. 武汉大学中南医院显微骨科,湖北,武汉,430071
2. 武汉理工大学生物材料与工程研究中心,湖北,武汉,430070 |
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| 基金项目： | 湖北省自然科学基金(2008CDB223) |
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| 摘 要： | 目的观察正交设计法在热致分相法(TIPS)制备生物可吸收储存式多孔药物载体中的应用。方法采用热致分相法(TIPS)制备生物可吸收储存式多孔药物载体,并以正交设计法优化生物可吸收储存式多孔药物载体的制备条件。结果用TIPS制备生物可吸收储存式多孔药物载体的孔隙率为68%~86%、相对密度为0.58~0.76g/cm3,弯曲强度和弹性模量分别为2.3MPa和51MPa以上。通过正交试验并综合分析优化实验结果为:影响生物可吸收储存式多孔药物载体成型的主要因素顺序是成型温度>浓度>冷冻时间;最佳成型条件为:体积(1,4-二氧六环)/质量(PDLLA/Col)比为10、成型温度为-70℃及冷冻时间为0.5小时。结论在使用热致分相法制备储存式载体材料过程中,通过正交试验予以优化,可使材料性能更加稳定,成型效率更高。
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| 关 键 词： | 正交试验法 储存式载体 热致分相 |
Application of the orthogonal experiment method in producing the bioabsorbable reservoir drug carrier |
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| Pan Zhenyu,Wan Tao,Wu Zhongjie. Application of the orthogonal experiment method in producing the bioabsorbable reservoir drug carrier[J]. Orthopaedic Biomechanics Materials and Clinical Study, 2011, 8(1): 8-11. DOI: 10.3969/j.issn.1672-5972.2011.01.003 |
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| Authors: | Pan Zhenyu Wan Tao Wu Zhongjie |
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| Affiliation: | Pan Zhenyu1,WanTao2,Wu Zhongjie2.1.Microsurgery Department of Zhongnan Hospital of Wuhan University,Wuhan,430071,2.Wuhan University of Technology Biomaterials & Engineering Research Center,430070,China. |
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| Abstract: | Objective To observe the influence of orthogonal experiment method in producing the bioabsorbable reservoir by the method TIPS.Methods The bioabsorbable reservoir durg carrier was produced by the method TIPS and the produce qualification was optimized by orthogonal experiment method.Results The hole rate of bioabsorbable reservoir drug carrier were about 68% to 86%,relatively density were 0.58 to 0.76 g/cm3,flexural strength 2.3MPa to 4.5 MPa and elastic modulus>51 MPa;the influence produce of mostly factor... |
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| Keywords: | Orthogonal experiment method Reservoir drug carrier TIPS |
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