超声联合HE4、B7-H4检测在卵巢癌早期诊断中的作用

目的 探讨超声联合血清人附睾蛋白4(HE4)、B7-H4检测在卵巢癌早期诊断中的作用.方法 回顾性分析113例卵巢肿瘤患者的临床资料,其中25例诊断为卵巢癌的患者作为观察组,88例卵巢良性肿瘤患者作为对照组.搜集所有患者的超声、HE4、B7-H4的检测结果,以病理检查结果为金标准,比较单项检查的差异以及联合检查的灵敏度...

Analysis of the Effect of Ultrasound combined with HE4 and B7-H4 on Early Diagnosis of Ovarian Cancer

Objective To explore the role of ultrasound combined with serum human epididymis protein 4(HE4)and B7-H4 in the early diagnosis of ovarian cancer.Methods The clinical data of 113 patients with ovarian tumors were analyzed retrospectively.25 patients with ovarian cancer were diagnosed as the observation group and 88 patients with benign ovarian tumors as the control group.The results of ultrasound,the levels of HE4 and B7-H4 in all patients were collected.The sensitivity and specificity of 3 kinds of single and combined examinations were compared using the gold standard as the results of pathological examination.The diagnostic value of different methods for ovarian cancer was analyzed.Results The levels of HE4,B7-H4 and Transvaginal color Doppler flow imaging(TV-CDFI)scores in the observation group were higher than those of the control group(P<0.05),and there was no significant difference in specificity(P>0.05).The sensitivity and accuracy of the examination of the HE4,ultrasound and B7-H4 were lower than those of the combined examination(P<0.05)by McNemar test,and there was a positive correlation between any 2 indexes(P<0.05).Conclusion Ultrasound combined with HE4 and B7-H4 detection is helpful for the early diagnosis of ovarian cancer,and is worthy of wide clinical use.