IGF-2、IGFBP-3在胎儿生长受限患者胎盘组织中的表达及其临床意义

目的 分析胎儿生长受限(FGR)患者胎盘组织中胰岛素样生长因子-2(1GF-2)、胰岛素样生长因子结合蛋白3(IGFBP-3)表达情况,并探讨其临床意义.方法 回顾性分析2017年12月至2019年12月本院经超声确诊FGR并住院分娩的110例患者(FGR组)的临床资料,另选择同期正常单胎足月分娩的孕妇110例为对照组...

Expression and clinical significance of IGF-2 and IGFBP-3 in placenta of patients with fetal growth restriction

Objective:To analyze the expression of insulin-like growth factor-2(IGF-2)and insulin-like growth factor binding protein-3(IGFBP-3)in placenta of patients with fetal growth restriction(FGR),and explore their clinical significance.Methods:A total of 110 patients with FGR diagnosed by ultrasound and delivered in our hospital from December 2017 to December 2019 were selected as FGR group,and 110 normal full-term pregnant women with normal singletons who delivered at the same period were selected as the control group.The placental tissues of the two groups were collected.General data of patients were compared between the two groups.The expression levels of IGF-2 mRNA and IGFBP-3 mRNA in placental tissue were detected by qRT-PCR.The expression levels of IGF-2 and IGFBP-3 protein were detected by immunohistochemistry.Spearman correlation analysis was used to analyze the correlation between IGF-2 and IGFBP-3 proteins in placenta of patients with FGR,and the binary logistic regression was used to analyze the influencing factors of FGR.Results:In the comparison of the general data between two groups,the fetal weight and early pregnancy related plasma protein A(PAPP-A)in FGR group were significantly lower than the control group(P<0.05).Compared with the control group,the expression level of IGF-2 mRNA and positive expression rate of IGF-2 protein in the placenta tissue of the FGR group were significantly decreased(P<0.05),while the expression level of IGFBP-3 mRNA and positive expression rate of IGF-2 protein were significantly increased(P<0.05).Spearman correlation analysis showed that there was a negative correlation between IGF-2 and IGFBP-3 protein expression(P<0.05).The binary logistic regression analysis showed that the abnormally lower expression of PAPP-A and IGF-2 mRNA,and the abnormally higher expression of IGFBP-3 mRNA in placental tissues were related to the occurrence of FGR(P<0.05).Conclusions:The abnormally lower expression of IGF-2 protein and the abnormally higher expression of IGFBP-3 protein in the placenta tissue may have a certain impact on the pregnancy outcome,and which are related to the occurrence of FGR.