TN-C和Ki-67的表达与非小细胞肺癌临床病理特征的相关性

目的探讨TN-C和Ki-67蛋白在非小细胞肺癌组织中的表达及其与非小细胞肺癌临床特征的相关性。方法选择459例非小细胞肺癌患者的肿瘤组织样本,免疫组化检测组织中TN-C和Ki-67的表达,计算其阳性率,并进一步分析二者的表达与非小细胞肺癌临床病理特征的相关性。结果(1)TN-C在不同性别、年龄、组织学类型、分化程度以及肿瘤位置的非小细胞肺癌组织中阳性表达差异无统计学意义(P>0.05);而与非淋巴结转移、肿瘤直径<3 cm、Ⅰ~Ⅱ期患者相比,淋巴结转移、肿瘤直径≥3 cm、Ⅲ~Ⅳ期患者TN-C阳性表达率显著升高(P<0.05)。(2)Ki-67在不同性别、年龄、肿瘤位置、淋巴结转移以及肿瘤直径的非小细胞肺癌组织中阳性表达差异无统计学意义(P>0.05);而与鳞癌、中高分化及Ⅰ~Ⅱ期患者相比,腺癌、低分化、Ⅲ~Ⅳ期患者Ki-67阳性表达率显著升高(P<0.05)。(3)TN-C表达阳性率与非小细胞肺癌患者淋巴结转移、肿瘤直径以及TMN分期均呈正显著相关性(γ>0,P<0.05),Ki-67表达阳性率与非小细胞肺癌患者分化程度和TMN分期均呈正显著相关性(γ>0,P<0.05)。结论TN-C和Ki-67的表达均与非小细胞肺癌的发生、进展等密切相关,可作为该肿瘤临床诊治的病理学依据。

Correlation between the Expression of TN-C and Ki-67 and the Clinicopathological Characteristics of Non-small Cell Lung Cancer

Objective To investigate the expression of Tenascin-C(TN-C)and Ki-67 protein in non-small cell lung cancer tissues and their correlation with the clinical features of non-small cell lung cancer.Methods Tumor tissue samples from 459 patients with non-small cell lung cancer were selected.The tumor tissue samples were preserved,and immunohistochemistry was used to detect the expression of TN-C and Ki-67 in the tissue.The positive rate was calculated,and the correlation between the expression of the 2 and the clinicopathological characteristics of non-small cell lung cancer was further analyzed.Results(1)There was no statistically significant difference in the positive expression of TN-C in non-small cell lung cancer tissues of different gender,age,histological type(P>0.05);Compared with patients with non-lymphatic metastasis,tumor diameter<3 cm,and stage Ⅰ~Ⅱ,the positive expression rate of TN-C in patients with lymphatic metastasis,tumor diameter≥3 cm and stage Ⅲ~Ⅳ was significantly higher(P<0.05).(2)The positive expression of Ki-67 in non-small cell lung cancer tissues of different gender,age,tumor location,lymph node metastasis and tumor diameter was not statistically different(P>0.05);Compared with squamous cell carcinoma,moderately well-differentiated and stage Ⅰ~Ⅱ patients,the positive expression rate of Ki-67 in adenocarcinoma,poorly differentiated and stage Ⅲ~Ⅳ patients was significantly higher(P<0.05).(3)The positive rate of TN-C expression was positively and significantly correlated with lymph node metastasis,tumor diameter and TMN staging in patients with non-small cell lung cancer(γ>0,P<0.05).The positive rate of Ki-67 expression was positively and significantly correlated with the degree of differentiation and TMN staging of patients with non-small cell lung cancer(γ>0,P<0.05).,and there was no significant correlation with histological type(P>0.05).Conclusion Both the expression of TN-C and Ki-67 are closely related to the occurrence and progression of non-small cell lung cancer,and can be used as the pathological basis for clinical diagnosis and treatment of this tumor.