清肾汤治疗糖尿病肾病随机对照临床研究

目的]观察清肾汤治疗糖尿病肾病的临床效果。方法]选取糖尿病肾病患者92例,随机分成治疗组52例与对照组40例,两组均采取口服降糖药物或胰岛素控制血糖,对照组口服缬沙坦治疗,治疗组在口服缬沙坦基础上加用清肾汤治疗,观察两组治疗前后空腹血糖、餐后2h血糖、糖化血红蛋白、血压、24h尿微量白蛋白排泄率和24h尿蛋白定量的变化。结果]治疗后两组患者空腹血糖、餐后2h血糖、糖化血红蛋白、血压均明显降低(P<0.05),在治疗组与对照组比较,无显著差异(P>0.05),但在降低24h尿微量白蛋白排泄率和24h尿蛋白定量方面,治疗组与对照组相比有显著性差异(P<0.05)。结论]清肾汤治疗糖尿病肾病有良好疗效,特别是在降低24h尿微量白蛋白排泄率和24h尿蛋白定量方面有显著的疗效。

Qingshen Decoction Treatment of Diabetic Nephropathy Randomized Controlled Clinical Study

Objective] To observe the Qingshen decoction in treatment of Diabetic Nephropathy Clinical effect.Methods]selection in patients with diabetic nephropathy 92 cases,were randomly divided into treatment group 52 cases and control group 40 cases in two groups,two groups were taking oral hypoglycemic agents or insulin to control blood sugar,the control group was treated with valsartan therapy,group therapy in oral valsartan combined with Qingshen decoction treatment,two groups were observed before and after treatment of fasting blood glucose,postprandial after the blood glucose,glycosylated hemoglobin,blood pressure,2 hours,24 hours urinary albumin excretion rate and 24 hours urine protein quantitative change.Results] after treatment in two groups of patients of fasting blood glucose,postprandial blood glucose,glycosylated hemoglobin,blood pressure and 2 hours were significantly decreased(P<0.05),in the treatment group compared with the control group,no significant difference(P>0.05),but 24h to reduce the urinary albumin excretion rate and 24 hours urine protein,the treatment group compared with the control group with significant difference(P<0.05).Conclusion] Qingshen decoction in treatment of diabetic nephropathy with good efficacy,especially in the lower 24h urinary albumin excretion rate and 24h urine protein has significant effects.