Lack of effect of 28 days of neuroleptic treatment on platelet benzodiazepine binding sites in schizophrenics |
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| Authors: | Z Tanne R Weizman L Karp Y Katz S Tyano M Gavish |
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| Affiliation: | Department of Pharmacology, Faculty of Medicine, Technion-Israel Institute of Technology, Haifa. |
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| Abstract: | Twenty-eight days of neuroleptic treatment of 11 schizophrenics aged 16-23 years did not affect the binding values of 3H-PK 11195 to platelets. This lack of effect was in contrast to reduced peripheral benzodiazepine binding sites (PBS) observed in platelets of schizophrenics medicated over 2 years. These results may indicate that neuroleptic-induced down-regulation of PBS is a time-dependent phenomenon. |
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