感染性胎膜早破孕妇血清一氧化氮的变化及其临床意义

目的 探讨胎膜早破孕妇血清一氧化氮(NO)浓度变化及其临床意义,为寻找胎膜早破的原因提供新的证据.方法 测定妊娠晚期(40例)、早产胎膜早破(28例)、不明原因足月胎膜早破(40例)、足月待产(40例)、足月临产(40例)孕妇的血清NO浓度,并进行比较.结果 不明原因足月胎膜早破孕妇血清NO浓度(95.364±3.562)μmol/L]较足月待产孕妇(75.020±3.416)μ mol/L]明显升高(P<0.01),更高于足月临产孕妇(31.457±3.859)μmol/L](P<0.01).早产胎膜早破孕妇血清NO浓度(101.256±3.124)μmol/L]较妊娠晚期孕妇(80.363±5.112)μmol/L]明显升高(P<0.01),与足月胎膜早破孕妇浓度相近(P=0.086).结论 不明原因足月胎膜早破孕妇血清NO浓度均明显较足月待产孕妇高,更高于足月临产孕妇.由于感染时NO浓度异常升高,提示胎膜早破与羊膜腔感染关系密切.

Change of serum nitric oxide in infectious premature rupture of membrane and its clinical significance

Objective To investigate the change of serum nitric oxide ( NO ) in premature rupture of membrane (PROM) and its clinical significance, so as to assess the role of NO in the mechanism of PROM . Method The serum NO in 40 advanced stage pregnant women,28 premature delivery PROM,40 unknown reason term pregnancy PROM ,40 term pregnancy ,40 term labor were detected and compared. Results The serum NO was higher in unknown reason term pregnancy PROM (95.364±3.562) (u)ol/L] than that in term pregnancy (75.020±3.416)(u)ol/L] and term labor (31.457±3.859)(u)ol/L](P<0.01). The serum NO was higher in premature delivery PROM (101.256±3.124)(u)ol/L] than that in advanced stage pregnant women (80.363±5.112)(u)ol/L] (P<0.0l),but similar with unknown reason term pregnancy PROM (P = 0.086). Conclusions The serum NO in PROM of term pregnancy significantly is higher than that of advanced stage and term labor women,indicates PROM relating to the increase of NO level. Because the increase of NO links to infection,it suggests that PROM relate closely to the amniotic infection.