心力衰竭患者血小板功能状态研究

目的　探讨慢性充血性心力衰竭患者血小板功能状态。　方法　应用放射免疫法测定 4 3例充血性心力衰竭患者和 4 3例非心力衰竭对照组患者的血小板膜表面α-颗粒膜蛋白 (GMP14 0 )及纤溶酶原激活抑制物 (PAI-1 ) ,超声心动图检测左室舒张末期内径 (LVEDd)及左室射血分数 (LVEF)。　结果　心衰组GMP14 0 ( 3 3 .9± 2 .1 μg/L)、PAI-1 ( 0 .80± 0 .1 9AU/ml)明显高于对照组 ( 1 8.1± 4 9μg/L、0 .71±0 .9AU/ml) ,P值分别 <0 .0 0 1、<0 .0 5;IVEF( 51 .2 %± 1 0 .5% )明显低于对照组 ( 71 .3 %± 8.2 % ) ,P <0 .0 1。心衰组不同心功能患者的血小板功能状态不同 ,心功能越差 ,LVEDd越大 ,LVEF越小。　结论　慢性充血性心力衰竭时血小板高度活化 ,血液呈高凝状态。血小板活化程度可能与心衰的病程及愈后有关。

Clinical study of platelet activation in patients with chronic heart failure

Objective To study the state of platelet activation in patients with chronic heart failure (CHF). Methods The levels of GMP 140 and PAI-1 on the surface of platelet in 43 CHF patients and 43 patients with normal heart function were detected by radio-immunoassay. Results The levels of GMP 140 and PAI-1 were significantly increased in heart failure patients. As the heart function deteriorated the levels of GMP 140 and PAI-1 were increased. Conclutions Platelet is markedly activated in CHF patients and that may play an important role in the process and prognosis of CHF.