坎地沙坦酯治疗轻中度高血压病人的疗效及安全性

目的：评价坎地沙坦酯治疗轻中度高血压病人的疗效及安全性。方法：人选48例轻中度高血压病人，经2周导人期后随机分人试验组和对照组各24例，按双盲、平行临床药理试验方法分别给予坎地沙坦酯8mg和氯沙坦50mg治疗。治疗4周后如不能有效控制血压，则将用药剂量加倍并维持到第8周末。检测病人治疗前、后不同时间的血压，心率，以及血、尿常规，肝、肾功能，并记录服药期间可能发生的不良事件。结果：试验组和对照组降压显效率均为100％，治疗后2周末收缩压(SBP)和舒张压(DBP)均已明显降低。此后血压继续下降，与治疗前相比，用药8周末试验组和对照组SBP分别下降20．3和16．4mmHg，DBP分别下降16．8和16．1mmHg。试验组中有1例病人服药期间出现头痛，1例病人感轻微胸闷和腹胀。两组病人血、尿常规，肝、肾功能均正常。结论：坎地沙坦酯治疗轻中度高血压病人降压效果良好，服用安全。

Clinical effectiveness and safety of candesartan cilexetil in treatment of patients with mild and moderate essential hypertension

Objective: To evaluate the clinical effectiveness and safety of candesartan cilexetil in treatment of patients with mild and moderate essential hypertension. Methods: Forty-eight patients were randomly and double-blindly divided into candesartan cilexetil(8 mg/d) group and losartan (50 mg/d) group after they had finished the induction treatment for 2 weeks. If the blood pressure was still over standard,the dosages of the drugs used were doubled from the 5th week till the end of 8th week. Blood pressure and heart rate were determined, and side effects were observed every 2 weeks. Before and after the trial, laboratory tests were performed. Results: The antihypertensive efficacy rates of both drugs were 100%. The systolic blood pressure(SBP)and diastolic blood pressure(DBP)in 2 groups decreased significantly after the teatment for 2 weeks. The SBP and DBP were decreased by 20.3 mmHg and 16.8 mmHg in candesartan cilexetil group, and 16.4 mmHg and 16.1 mmHg in losartan group at the end of 8-week treatment. Except appearance of headache in one patient and appearance of mild chest discomfort and abdominal distension in another patient, the others had no discomfortable feeling.All laboratory tests were normal. Conclusion: Candesartan cilexetil can be used in treatment of patients with mild and moderate essential hypertension effectively and safely.