美降脂对大鼠实验性肾小球损伤的保护作用

目的　探讨美降脂防治肾小球损伤的作用。方法　１６ 只雄性Ｗｉｓｔａｒ 大鼠阿霉素诱导肾病综合征模型后给予高脂饲料喂养，并随机分为对照组和治疗组。治疗组每日予美降脂４ ｍｇ／ｋｇ。２ 周测１ 次２４ ｈ 尿蛋白，４ 周测１ 次血脂，１２ 周肾组织光镜检查。结果　对照组肾脏病理积分及含有泡沫细胞肾小球百分率分别为１．８１±０．１１％ 和４３ ．２１ ±４ ．８９ ％ ，而治疗组分别为０．９１±０．１７％ 和２１．０９±３．３１％ ，治疗组明显低于对照组（Ｐ＜ ０．０１） 。１０ 周后治疗组２４ ｈ 尿蛋白为２０８．９ ±６０．４ ｇ／Ｌ，１２ 周为１６０．５ ±４８．６ ｇ／Ｌ，明显低于对照组（２７６ ．１±５７ ．３ ｇ／Ｌ；２６２．４±７２．７ ｇ／Ｌ）（Ｐ＜ ０．０５ 和０ ．０１） 。结论　美降脂能明显降低血脂，减轻高脂血症造成的肾小球损伤和减少尿蛋白的排泄量。

Protective effect of lovastatin on the experimental glomerular injury in rats

Objective To study the effect of Lovastatin on experimental glomerular injury. Methods After nephritic syndrome model was induced with adriamycin, 16 male Wistar rats were fed with high lipid diet and divided randomly into the control group and treatment group. A dose of 4 mg/kg of Lovastatin was given daily only in the treatment group. The 24-hour urinary protein was measured every two weeks, and the serum lipid and protein were determined every four weeks. After 12 weeks, renal tissues were examined by light microscopy. Results The level of pathomorphologic score and percentage of glomerules with foam cell were 1.81±0.11 and 43.21±4.89% respectively in the control group, and 0.91±0.17 and 21.09±3.31% in the treatment group.Both pathomorphologic score and percentage of glomerules with foam cells were significantly lower in the treatment group than in the control group (P<0.01). The values of the 24-hour urinary protein excretion in the treatment group (10 weeks: 208.9±60.4 g/L; 12 weeks: 160.5±48.6 g/L) were lower than those seen in the control group (10 weeks: 276.1±57.3 g/L ; 12 weeks: 262.4±72.7 g/L) (P<0.05 and P<0.01) after ten weeks. Conclusions Lovastatin seems to significantly alleviate lipidemia, to ameliorate hyperlipidemia-induced glomerrular injury and to decrease urinary protein excretion.