茵陈加味汤联合熊去氧胆酸治疗妊娠肝内胆汁淤积症62例

目的：观察茵陈加味汤联合熊去氧胆酸治疗妊娠肝内胆汁淤积症（ intrahepatic cholestasis of pregnancy，ICP）的疗效。方法：采用前瞻性研究方法，将2010年至2012年本院收治的妊娠肝内胆汁淤积症孕妇108例随机分为A、B两组，A组采用茵陈加味汤联合熊去氧胆酸治疗（62例），B组采用熊去氧胆酸治疗（46例）。比较两组治疗效果及妊娠结局。结果：治疗结束时，A组治疗后皮肤瘙痒评分及TBA、AST、ALT、CG值均降低，且较B组低。两组瘙痒评分和AST、ALT值比较差异有统计学意义（ P＜0．05），剖宫产率、产后出血率、羊水粪染率比较差异也有统计学意义（P＜0．05）。结论：茵陈加味汤联合熊去氧胆酸治疗ICP能够提高ICP的疗效，值得临床推广。

Effect of ursodeoxycholic acid combined with modified Artemisiae Scopariae decoction in intrahepatic cholestasis of pregnancy

Objective： to observe the efficacy of ursodeoxycholic acid combined with modified Artemisiae Scopariae decoction in the treatment for intrahepatic cholestasis of pregnancy .Methods：108 cases with ICP had been chosen and randomly divided into two groups：the A group（ the ursodeoxycholic acid combined with modified Artemisiae Scopariae decoction group ,62 case ） and the B group （ the ursodeoxycholic acid group ,46 case ） , the clinical effect were compared before and after traetment .Results：The reduction of itch score , AST,ALT of the A group were significantly decreased than that in the B group （ P ＆lt;0.05 ） .The TBA, CG of the A group were decreased than in the B group .Comparing the two groups , the incident of Cesarean section , Postpartum hemorrhage and the incident of meconium-stained amniotic fluid were significant （P＆lt;0.05）.Conclusion：It is effective to treat ICP with combination of ursodeoxycholic acid and modified Artemisiae Scopariae decoction injection .