2型糖尿病患者合并非酒精性脂肪肝的临床观察

目的：观察2型糖尿病患者（T2DM）合并非酒精性脂肪肝（NAFLD）的临床特点，分析T2DM合并NAFLD的危险因素。方法：选取138例住院的T2DM患者，分别测量血压、身高、体重，计算体质指数（BMI）；同时测定空腹血糖（FPG）、餐后2小时血糖（2hPG）、甘油三酯（TG）、高密度脂蛋白胆固醇（HDL）、丙氨酸转氨酶（ALT）、天冬氨酸转氨酶（AST）、空腹胰岛素（FINS）及餐后2小时胰岛素（PINS）。所有对象依B超检查结果是否脂肪肝分为NAFLD组（54例）和非脂肪肝（NFLD）组（84例）。对两组相关指标进行对比分析。结果：T2DM中NAFLD的患病率为39.2%，NAFLD组血清肝酶水平升高者为69.23%；T2DM合并NAFLD组患者BMI、TG、FINS、PINS水平明显升高（P＜0.05或P＜0.01）。结论：T2DM患者中NAFLD呈现较高的患病率；BMI、TG、FINS、PINS可能是T2DM合并NAFLD的主要危险因素。

Analysis of clinical characteristic of non-alcoholic fatty liver disease in patients with Type 2 diabetes mellitus

To investigate the clinical characteristic of non-alcoholic fatty liver disease with type 2 diabetes mellitus , and to analysis its risk factors . Method：138 patients with T2DM were selected . Biochemical tests and liver ultrasound examination were retrieved. Biochemical indices between T2DM patients with and without NAFLD （NAFLD and NFLD） were compared . Results：The prevalence of NAFLD in T2DM patients was 39 . 2%, among which 69 . 23% had the elevated liver enzymes . Compared with NFLD group , the BMI , triglycerid , FINS , PINS and ALT , AST in NAFLD group were significantly higher （P〈0 . 05 or P〈0 . 01）. Conclusion：There is high prevalence of NAFLD in patients with type 2 diabetes mellitus . BMI , TG , FINS and PINS were major risk factors for T2DM patients with NAFLD .