Acute respiratory distress syndrome in children with acute iron poisoning: the role of intravenous desferrioxamine |
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Authors: | A S Ioannides J M Panisello |
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Institution: | (1) Department of Paediatric Intensive Care, Royal Manchester Children's Hospital, Hospital Road, Pendlebury, Manchester M27 4HA, UK e-mail: aioannides@aioannides.ndirect.co.uk Tel.: +44-161-727-2468; Fax: +44-161-727-2198, GB |
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Abstract: | The acute respiratory distress syndrome is a rare but potentially fatal complication of severe acute iron poisoning and its
pathogenesis has been linked with direct and indirect iron toxicity as well as the use of the chelator drug desferrioxamine.
We report a case of severe acute respiratory decompensation in a child treated according to the current protocol for chelation
therapy and discuss its implications.
Conclusion We believe that the efficacy and safety of chelation therapy in severe acute iron poisoning may be improved by targeting
the initial high levels of readily chelatable serum iron with adequate doses of desferrioxamine without prolonging its use
unnecessarily.
Received: 18 December 1998 / Accepted: 2 June 1999 |
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Keywords: | Acute respiratory distress syndrome Acute iron poisoning Desferrioxamine |
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