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Regulation of pancreatic cell differentiation and morphogenesis |
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| Authors: | Humphrey Rohan K Smith Murray S Tuch Bernard E Hayek Alberto |
| Affiliation: | The Islet Research Laboratory, Whittier Institute for Diabetes, Department of Pediatrics, School of Medicine, University of California San Diego, La Jolla, California, USA;;School of Anatomy, The University of New South Wales, Sydney, New South Wales, Australia;and;Pancreas Transplant Unit, Department of Endocrinology, Prince of Wales Hospital, Sydney, New South Wales, Australia |
| Abstract: | Abstract: Organogenesis requires tissue interactions to initiate the cascade of inductive and repressive signals necessary for normal organ development. Tissue interactions initiate the pancreatic lineage within the primitive foregut endodermal epithelium and continue to direct the morphogenesis and differentiation of the endocrine, exocrine and ductal portions of the pancreas. An understanding of the mechanisms controlling pancreatic growth would enable the development of alternative therapies for diseases such as type 1 diabetes. |
| Keywords: | β cell differentiation mesenchyme morphogenesis pancreas |
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