癌钙调蛋白在神经系统及视神经再生方面的研究进展

癌钙调蛋白（OM）是钙结合蛋白家族中的一员,属于肌钙蛋白c超家族,它具有不同于其他钙结合蛋白的特异性钙结合（CD）区域。通过研究其结构和分布特征,发现OM在调节细胞的电活动、调控细胞内信号传导通路及细胞周期等方面发挥着重要的作用。近年来,OM在促进神经轴突再生方面的研究是目前研究的热点之一,尤其是在视神经再生的研究方面取得了一定的成绩,并有待运用于临床。OM促进视神经再生的作用为解决脊髓和脑神经的再生性难题打下了基础。对OM的概念、组织的分布、主要的作用及机制、与视神经再生的关系方面进行综述。

Recent advancement about oncomodulin in regeneration of nerve system and optical nerve

Oncomodulin(OM) is a kind of Ca-bind protein(CABP),and it belongs to the tropon in C super family.It different from other CABP because of its special domain(CD domain) which could bind with Ca2+.Multiple functions of OM have been determined during the study of its construction and distribution.It plays very important role in adjusting cell electric activity,regulating cell signal conduction passageway and cell cycle.In recent years,the study on OM promoting axon regeneration is emerging,especially in the regeneration of optical nerve.It offers a basis for solving the regeneration of spinal cord and cranial nerve.The concept,construction and distribution,action mechanism and its relationship with regeneration of optical nerve were reviewed in this article.