| Kringle结构及其在眼部新生血管性疾病中的应用 |
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| 引用本文： | 苏莉. Kringle结构及其在眼部新生血管性疾病中的应用[J]. 眼科研究, 2011, 29(6): 565-569. DOI: 10.3760/cma.j.issn.2095-0160.2011.06.019 |
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| 作者姓名： | 苏莉 |
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| 作者单位： | 上海交通大学附属第一人民医院眼科,200080 |
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| 基金项目： | 上海市科技启明星计划项目(追踪),上海交通大学医学院博士点创新基金项目 |
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| 摘 要： | 以异常新生血管形成为主要病理变化的新生血管性眼病是l临床常见、治疗棘手的致盲性眼病,一旦发生往往难以逆转,将导致严重的视力损害。近年来研究发现体内多种内源性蛋白所包含的带双硫键三环蛋白结构区的kringle结构具有抑制新生血管的作用,因此kringle结构域被认为是具有抑制新生血管作用的独立保守结构和功能单位。就近年来发现的具有抑制新生血管作用的kringle结构及其抑制眼部新生血管的作用进行综述,以期对研究新生血管抑制剂有所提示。
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| 关 键 词： | 新生血管性眼病 病理性 血管生成抑制剂 带双硫键三环蛋白结构区 |
Kringle domain and its inhibition of ocular neovascularization |
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| SU Li. Kringle domain and its inhibition of ocular neovascularization[J]. Chinese Ophthalmic Research, 2011, 29(6): 565-569. DOI: 10.3760/cma.j.issn.2095-0160.2011.06.019 |
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| Authors: | SU Li |
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| Affiliation: | SU Li, XU Xun. (Department of Ophthalmology, Shanghai First People＇s Hospital, Affiliated Shanghai Jiaotong University, Shanghai 200080, China) |
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| Abstract: | Ocular neovascularization,abnormal formation of new vessels from pre-existing capillaries,is a special pathologic change of many ocular diseases,including diabetic retinopathy and retinopathy of prematurity,etc..Ocular neovascular diseases comprise the common causes of blindness in millions of people.Recent studies showed that kringle domains from many endogenous proteins inhibit the proliferation and migration of endothelial cells in vitro and neovascular formation in vivo.Hence kringle domain with conservative structure has been considered as a potential inhibitor of neovascularization.The update studies on antiangiogenic kringle domains and its inhibition on ocular neovascularization were summarized. |
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| Keywords: | Ocular neovascular disease Pathologic Angiogenesis inhibitors Kringles domains |
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