| FHIT和p16基因甲基化与肺癌的发生 |
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| 引用本文： | 亢春彦,肖红,吴逸明.FHIT和p16基因甲基化与肺癌的发生[J].癌变．畸变．突变,2009,21(4). |
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| 作者姓名： | 亢春彦 肖红 吴逸明 |
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| 作者单位： | 1. 河南职工医学院病理学教研室,河南,郑州,450003
2. 郑州大学公共卫生学院劳动卫生学及卫生毒理学教研室,河南,郑州,450052 |
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| 摘 要： | 背景与目的:探讨FHIT和p16基因甲基化与肺癌发生之间的关系. 材料与方法:采用甲基化特异性PCR检测59例原发性肺癌组织,相对应的32例正常组织及11例支气管鳞状化生组织中FHIT基因、p16基因启动子区CpG岛甲基化状况.结果:肺癌组织和正常肺组织中的FHIT基因甲基化率分别为37.3%(22/59)、0.0%(0/32),两组间的差异有统计学意义(P<0.01);支气管鳞状化生组织FHIT基因甲基化阳性率为18.1%(2/11).肺癌组织和正常肺组织中的p16基因甲基化率分别为50.8%(30/59)、0.0%(0/32),两组间的差异具有统计学意义(P<0.01);支气管鳞状化生组织p16基因甲基化阳性率为18.1%(2/11).肺癌患者吸烟组中FHIT、p16基因甲基化联合检测的阳性率为90.6%(29/32),与非吸烟组(33.3%.9/27)相比较,其差异具有统计学意义(P<0.05).结论: FHIT基因和p16基因启动子区甲基化可能与肺癌的发生有关.
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| 关 键 词： | FHIT基因 p16基因 甲基化 肺癌 甲基化特异性聚合酶链技术 |
Relationship between Methylation of FHIT and p16 Genes and Lung Cancer |
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| KANG Chun-yan,XIAO Hong,WU Yi-ming.Relationship between Methylation of FHIT and p16 Genes and Lung Cancer[J].Carcinogenesis,Teratogenesis and Mutagenesis,2009,21(4). |
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| Authors: | KANG Chun-yan XIAO Hong WU Yi-ming |
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| Institution: | KANG Chun-yan1,XIAO Hong1,WU Yi-ming2,(1.Department of Pathology,Henan Medical College for Staff , Workers,Zhengzhou 450003,2.Occupational Health , Toxicology,College of Public Health,Zhengzhou University,Zhengzhou 450052,Henan,China) |
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| Abstract: | BACKGROUND AND AIM: To illustrate the relationship between the methylation of FHIT and p16 genes and the development of lung cancer.MATERIALS AND METHODS: Methylation of the promoters of FHIT gene and p16 gene was evaluated by methylation-specific PCR in 59 lung cancer tissues,32 adjacent non-carcinoma tissues and 11 bronchal epithelial squamous tissues.RESULTS: FHIT methylation in lung cancer tissue samples,adjacent non-carcinoma tissue samples were 37.3%(22/59) and 0%(0/32)respectively,with significant di... |
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| Keywords: | FHIT gene p16 gene methylation lung cancer methylation-specific PCR |
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