Demonstration of A-currents in pancreatic islet cells |
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Authors: | Paul A Smith Krister Bokvist Patrik Rorsman |
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Institution: | (1) Department of Medical Physics, P.O. Box 33031, S-400 33 Gothenburg, Sweden;(2) Present address: University Laboratory of Physiology, Parks Road, OX1 3PT Oxford, UK |
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Abstract: | Voltage-activated K+ currents resistant to TEA but blockable by 4-AP were recorded from mouse pancreatic islet cells. These currents first become observable during depolarizations to voltages more positive than –40 mV, reaching a peak amplitude of 120±34 pA at +6 mV (n=4), display rapid turn on (=3.3±1.1 ms at +6 mV) and inactivate completely within 250 ms (=65±5 at +6 mV). The current is subject to steady-state inactivation. The midpoint (V
h) of the inactivation curve (h) was observed at –72±2 mV. The properties of this current resemble those reported for the A-current in neurons. |
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Keywords: | A-currents K+-channels -cells" target="_blank">gif" alt="beta" align="MIDDLE" BORDER="0">-cells Endocrine pancreas |
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