阿托伐他汀对高脂血症患者颈动脉内膜中层厚度及凝血系统的影响

目的　观察阿托伐他汀调脂同时对高脂血症患者颈动脉内膜中层厚度 (IMT)及凝血系统的影响。方法　选择高脂血症患者 35例为血脂紊乱组 ,口服阿托伐他汀 10mg·qd ,12周 ,血脂正常者 35例为正常对照组 ,分别对血脂紊乱组治疗前及 12周后两组进行血脂总胆固醇 (TC)、甘油三酯 (TG)、低密度脂蛋白胆固醇 (LDL C)、高密度脂蛋白胆固醇 (HDL C)、IMT、纤维蛋白原 (FIB)、凝血酶时间 (TT)、活化部分凝血酶时间 (APTT)、凝血酶原时间 (PT)检查。结果　与治疗前比较 ,血脂紊乱组治疗 12周后的TC、TG、LDL C、FIB均有显著降低 (P均 <0 0 1) ,HDL -C显著升高 (P <0 0 5 ) ,颈动脉IMT显著变薄 (P <0 0 5 ) ,TT、APTT均有显著延长 (P均 <0 0 1)。PT显著升高 (P <0 0 5 )。TC、TG、LDL C、HDL C、IMT、FIB、PT均接近血脂正常组各指标 ,比较无显著差异 (P >0 0 5 )。TT、APTT均超出血脂正常组 ,比较有显著差异 (P <0 0 5 )。结论　阿托伐他汀在有效调脂同时可发挥其非调脂作用 ,逆转或延迟颈动脉IMT的进程 ,并改善凝血系统。

Effect of Atorvastatin on Intima-media Thickness of the Common Carotid Artery and Blood Coagulation in Hyperlipidemic Patient

Objective To study the effect of atorvastatin on intima-media thickness(ITM)of the common carotid artery and coagulative system in hyperlipidemic patierts. Methods Thirty five hyperlipidemic patients were received atorvastatin 10 mg qd for 12 weeks. TC,TG,LDL-C,HDL-C,IMT,fibrinogen(FIB),thrombin time (TT),activated partial thromboplastin time(APTT) and prothrombin time (PT) were determind in hyperlipidemic group before and after treatment. The intima-media thickness of carotid artery was measured using echography. Thirty-five normol lipidemic subjects serued as control. Results TC,TG,LDL-C,IMT,FIB were decreased significantly( P< 0.01)in hyper-lipidemic group after 12 weeks. HDL-C,PT TT,APTT were increased significantly ( P< 0.05). Compared with normal lipidemic group,TC,TG,LDL-C,HDL-C,IMT,FIB and PT were not significantly different( P> 0.05),while TT,APTT were significantly increased ( P< 0.05). Conclusion Atorvastatin treatment not only regresses the structural changes in IMT of the common carotid artery but also improve disorder of coagulation system in hyperlipidemic patients.