Myostatin (GDF-8) inhibits chondrogenesis and chondrocyte proliferation in vitro by suppressing Sox-9 expression |
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| Authors: | Elkasrawy Moataz Fulzele Sadanand Bowser Matthew Wenger Karl Hamrick Mark |
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| Affiliation: | Department of Cellular Biology & Anatomy, Medical College of Georgia , Georgia Health Sciences University, Augusta, USA. |
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| Abstract: | Here, we investigate a possible direct role for myostatin in chondrogenesis. First, we examined the effects of myostatin on the proliferation of bone marrow stromal cells (BMSCs) and epiphyseal growth plate (EGP) chondrocytes (EGPCs) isolated from myostatin-deficient mice. Results show that myostatin deficiency is associated with a significant (P?
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