一起由大白鼠引起的肾综合征出血热爆发的调查报告

1983年4~8月,某院实验室和动物室的工作人员中首次爆发了HFRS,发生病例16人,罹患率27%。其中教师6人,研究生2人,实验技术人员3人,实习生2人和动物饲养员3人。病人一般症状轻,无一例死亡。用间接荧光技术检查各室工作人员42人。其中有16例病人HFRS抗体全部阳性,而26名健康者中,有4人杭体阳性,提示隐性感染的存在。检查了126只大白鼠的肺,HFRS病毒抗原阳性21只,带毒率为16.7%。流行病学调查说明大白鼠为本次HFRS爆发的传染源。

Survey of An Outbreak of Hemorrhagic Fever with Renal Syndrome As A Result of Experimental white Rat Infection

There was an outbreak of hemorhagic fever with renal syndrome (HFRS) among the staff members in a laboratory and animal room of a college during April to August 1983. 16 out of 60 (27%) staff had HFRS and the disease appeared to be a mild but typical clinical course. The patients composed of 6 teachers, 2 postgraduate students, 3 technicians, 2 students of practice, and 3 animal raisers. The HFRS antibody was tested on 42 staff, who has worked in the laboratory and animal room, with indirect immunofluoresent technique. The results showed that the antibody titers were significantly raised in all 16 patients, and were positive in 4 out of other staff who had no HFRS. The HFRS antigen was detected in the lungs of 21 out of 126 rats (16.7%) with the immunofluorecentassay. The epidemiological study suggested that rats were the source of infection in this outbreak.