| 胆固醇7-羟化酶CYP7A1表达及调控相关研究进展 |
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| 引用本文： | 邢万佳,高聆,赵家军. 胆固醇7-羟化酶CYP7A1表达及调控相关研究进展[J]. 世界华人消化杂志, 2012, 0(16): 1439-1446 |
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| 作者姓名： | 邢万佳 高聆 赵家军 |
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| 作者单位： | 中国人民解放军济南军区第456医院内分泌科;山东大学附属省立医院中心实验室;山东大学附属省立医院内分泌科 |
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| 摘 要： | 胆固醇7-羟化酶(cholesterol 7-alpha hydroxy-lase,CYP7A1)是胆汁酸合成代谢经典途径的限速酶.其表达不仅具有昼夜节律,而且可由基因多态性、饮食、激素、细胞因子及药物等多种因素调节.CYP7A1的基因多态性与疾病及对药物的治疗反应存在相关性,同时多种核受体参与了CYP7A1的表达的调控,共同组成了转录激活/抑制级联网络,维持体内胆汁酸合成及脂质动态平衡.本文主要对CYP7A1表达、调控及与疾病及治疗反应的相关性等方面的研究进行综述.
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| 关 键 词： | 胆固醇7-羟化酶 基因多态性 昼夜节律 核受体 |
Expression and regulation of cholesterol 7 alpha-hydroxylase: An update |
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| Wan-Jia Xing, Ling Gao, Jia-Jun Zhao. Expression and regulation of cholesterol 7 alpha-hydroxylase: An update[J]. World Chinese Journal of Digestology, 2012, 0(16): 1439-1446 |
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| Authors: | Wan-Jia Xing Ling Gao Jia-Jun Zhao |
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| Affiliation: | , Department of Endocrinology, the 456th Hospital of Jinan Military Command of Chinese PLA, Jinan 250031, Shandong Province, China , Department of Central Laboratory, Provincial Hospital Affiliated to Shandong University, Jinan 250022, Shandong Province, China , Department of Endocrinology, Provincial Hospital Affiliated to Shandong University, Jinan 250022, Shandong Province, China |
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| Abstract: | Cholesterol 7-alpha hydroxylase (CYP7A1) is the first and rate-limiting enzyme in the neutral pathway of bile acids synthesis. The expression of CYP7A1 can be regulated not only by diurnal rhythm, but also by gene polymorphism, diet, hormones, cytokines and drugs. CYP7A1 gene polymorphism is associated not only with some diseases but also with response to drug therapy. A cascade network consisting of multiple nuclear receptors is involved in the regulation of CYP7A1 expression to control bile acid synthesis and lipid metabolism. |
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| Keywords: | Cholesterol 7-alpha hydroxylase Gene polymorphism Diurnal rhythm Nuclear receptor |
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