Candida albicans and Candida glabrata clinical isolates exhibiting reduced echinocandin susceptibility |
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Authors: | Katiyar Santosh Pfaller Michael Edlind Thomas |
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Institution: | Department of Microbiology and Immunology, Drexel University College of Medicine, Philadelphia, PA 19129, USA. |
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Abstract: | A recognized hotspot for mutations conferring reduced echinocandin susceptibility (RES) is residue S645 of Candida albicans Gsc1(Fks1). We report that the mutation F641Y is associated with RES in a C. albicans isolate. The analogous Fks2 residue is mutated F to V in a Candida glabrata RES isolate; the introduction of this mutation into susceptible C. glabrata confirmed its role in RES. Y641-equivalent Fks residues were identified in intrinsically RES Fusarium species and Candida guilliermondii. |
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