Classification and clinical features of motor neurone diseases and motor neuropathies in adults |
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Authors: | Michael Donaghy |
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Institution: | (1) University Department of Clinical Neurology, Radcliffe Infirmary, Woodstock Road, Oxford OX2 6HE, UK Tel.: +44-1865-224698 Fax: +44-1865-790493, GB |
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Abstract: | The term motor neurone disease encompasses combined upper and lower motor neurone disorders (amyotrophic lateral sclerosis),
pure lower motor neurone disorders (spinal muscular atrophies, multifocal motor neuropathies, post irradiation lumbosacral
radiculopathy, post-polio syndrome, hereditary bulbar palsy) and pure upper motor neurone disorders (primary lateral sclerosis,
hereditary spastic paraplegia, neurolathyrism, Konzo). The chief clinical and electrophysiological criteria for these different
disorders are discussed, with particular attention to diagnostically distinctive characteristics of each. Age of onset, and
inheritance are considered as additional diagnostic features.
Received: 8 July 1998 Accepted: 23 July 1998 |
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Keywords: | Motor neurone disease Amyotrophic lateral sclerosis Multifocal motor neuropathy |
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