维生素C防治急性心肌梗死再灌注损伤临床观察

目的探讨维生素c注射液对急性心肌梗死（AMI）静脉溶栓治疗后再通率及并发症的影响。方法128例AMI患者随机分成维生素c组（68例）和对照组（60例）。两组均以尿激酶常规溶栓治疗。维生素c组在溶栓治疗前予维生素C注射液5．0g加入生理盐水100mL静滴，比较两组再通标准各项指标及并发症情况。结果两组再通率相似（61．76％和58．33％），而维生素c组再灌注心律失常发生率为36．76％，明显低于对照组的63．33％（P〈0．05）；心力衰竭及梗死后心绞痛发生率（8．82％和7．35％）均明显低于对照组（20．58％和16．67％）（P〈0．05）；休克及总病死率也低于对照组。结论维生素c注射液配合尿激酶溶栓治疗AMI，可提高疗效，减少再灌注心律失常等并发症，降低病死率。

Effect of Vitamin C Therapy on Reperfusion Injury of Acute Myocardial Infarction

Objective To study the effects of Vitamin C on reperfusion rate and complication of acute myocardial infarction （AMI）after thrombolytic therapy. Methods 128 patients of AMI with thrombolytic therapy divided randomly into trail（68 Cases）and control group（60 cases）. The trail group received Vitamin C 5.0g before received urokinase thrombolytic therapy. The recanalization rates and indications are investigated. Results The results showed that the recancalization rates were no significantly between the trail and control group（61.76% and 58.33%）. The reperfusion arrhythmias rates were significantly（ P〈 0.05 ） between the trail and control group（36.76% and 63.33%）. Heart failure and postinfarction angina pectoris rates（8.82% and 7.35%） were lower than control group（20.58% and 16.67%）,shock and mortality were lower too. Conclusion Vitamin C and thrombolytic therapy of AMI can increase the curative, decrease reperfusion arrhythmias, etc. and mortality