The mammalian RNA-binding protein staufen2 links nuclear and cytoplasmic RNA processing pathways in neurons |
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| Authors: | Michaela Monshausen Niels H Gehring Kenneth S Kosik |
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| Institution: | (1) Department of Neurology, Brigham and Women’s Hospital, and Harvard Medical School, 02115 Boston, MA;(2) Molecular Medicine Partnership Unit, University of Heidelberg & European Molecular Biology Laboratory, Heidelberg, Germany;(3) Neuroscience Research Institute, University of California, 93106-5060 Santa Barbara, CA |
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| Abstract: | Members of the Staufen family of RNA-binding proteins are highly conserved cytoplasmic RNA transporters associated with RNA
granules. staufen2 is specifically expressed in neurons where the delivery of RNA to dendrites is thought to have a role in plasticity. We
found that Staufen2 interacts with the nuclear pore protein p62, with the RNA export protein Tap and with the exon-exon junction
complex (EJC) proteins Y14-Mago. The interaction of Staufen2 with the Y14-Mago heterodimer seems to represent a highly conserved
complex as the same proteins are involved in the Staufen-mediated localization of oskar mRNA in Drosophila oocytes. A pool of Staufen2 is present in neuronal nuclei and colocalizes to a large degree with p62 and
partly with Tap, Y14, and Mago. We suggest a model whereby a set of conserved genes in the oskar mRNA export pathway may be recruited to direct a dendritic destination for mRNAs originating as a Staufen2 nuclear complex. |
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| Keywords: | Staufen nuclear pore protein p62 Tap Y14 Mago RNA transport RNA export RNA processing NMD EJC |
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