| The Expression of Interleukin-23 （p19/p40） and Inteleukin-12 （p35/p40） in Psoriasis Skin |
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| 引用本文： | 陈旭娥,谭志建,岳青,刘厚君,刘志香,李家文.The Expression of Interleukin-23 （p19/p40） and Inteleukin-12 （p35/p40） in Psoriasis Skin[J].华中科技大学学报(医学英德文版),2006,26(6):750-752. |
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| 作者姓名： | 陈旭娥 谭志建 岳青 刘厚君 刘志香 李家文 |
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| 作者单位： | Department of Dermatology Union Hospital Tongji Medical College Huazhong University of Science and Technology，Department of Dermatology Union Hospital Tongji Medical College Huazhong University of Science and Technology，Department of Dermatology Union Hospital Tongji Medical College Huazhong University of Science and Technology，Department of Dermatology Union Hospital Tongji Medical College Huazhong University of Science and Technology，Department of Dermatology Union Hospital Tongji Medical College Huazhong University of Science and Technology，Department of Dermatology Union Hospital Tongji Medical College Huazhong University of Science and Technology，Wuhan 430022 China，Wuhan 430022 China，Wuhan 430022 China，Wuhan 430022 China，Wuhan 430022 China，Wuhan 430022 China |
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| 摘 要： | Interleukin-12 (IL-12), which is composed of p35 and p40 subunit, is a proinflammatory Th1-inducing cy-tokine. Besides IL-12, p40 can be covalently linked to a p35-related protein p19. This heterodimer is known as IL-231]. IL-12 promotes the development of naive T cells, whereas IL-23 mediates late-stage inflammation. In this study, the expression of IL-12p35/p40 mRNA and IL-23p19/p40 mRNA were analyzed by using reverse translation-polymerase chain reaction (RT-PCR) in order to pro…
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| 关 键 词： | 白细胞间素-23 基因表达 牛皮癣 治疗 |
| 收稿时间： | 2006-10-20 |
| 修稿时间： | 2006-10-20 |
The expression of interleukin-23 (p19/p40) and inteleukin-12 (p35/p40) in psoriasis skin |
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| Xu’e Chen,Zhijian Tan,Qing Yue,Houjun Liu,Zhixiang Liu,Jiawen Li.The expression of interleukin-23 (p19/p40) and inteleukin-12 (p35/p40) in psoriasis skin[J].Journal of Zuazhong University of Science and Technology: Medical Edition,2006,26(6):750-752. |
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| Authors: | Xu’e Chen Zhijian Tan Qing Yue Houjun Liu Zhixiang Liu Jiawen Li |
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| Institution: | Department of Dermatology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology,Wuhan 430022, China |
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| Abstract: | In order to investigate the mRNA expression and function of interleukin-23 (p19/p40) and interleukin-12 (p35/p40) in the psoriatic lesion, no-lesion and normal human skin, reverse transcrip-tase-polymerase chain reaction (RT-PCR) was used to detect the expression of IL-23 (p19/p40) and IL-12 (p35/p40). The results showed that the expression of IL-23p19 mRNA and p40 (IL-12/IL-23) mRNA were higher in psoriatic lesion than those of non-lesional skin and normal skin. The levels of IL-23p19 mRNA and p40 (IL-12/IL-23) mRNA were higher in psoriatic non-lesional skin than nor-mal skin. However, no significant difference was found in the level of IL-12p35 mRNA among the psoriatic lesional skin, non-lesional skin and normal skin. It was suggested that IL-23 might be more important in the pathogenesis of psoriasis than IL-12. |
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| Keywords: | psoriasis IL-23p19 IL-23/IL-12p40 IL-12 p35 |
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