| 吲哚美辛β-环糊精包合物的制备 |
| |
| 引用本文： | 陈宝福,王福纯. 吲哚美辛β-环糊精包合物的制备[J]. 黑龙江医药, 2009, 22(2): 161-162 |
| |
| 作者姓名： | 陈宝福 王福纯 |
| |
| 作者单位： | 哈药集团制药总厂,150086;哈药集团制药总厂,150086 |
| |
| 摘 要： | 制备吲哚美辛β-环糊精包合物考察其有关性质。方法：采用共沉淀法制备吲哚美辛β-环糊精包合物．结果：采用显微镜法和红外光谱法进行鉴定，表明吲哚美辛与β-环糊精确已形成包合物，含量测定证明包合物主、客分子比为1：1．结论：吲哚美辛β-环糊精包合成功，明显提高吲哚美辛的溶解度、溶出速度。
|
| 关 键 词： | 吲哚美辛 β-环糊精 包合物 |
preparation of Inclusion Compound of Indometacin B-cyclodextrin |
| |
| Affiliation: | Chen Baofu, et al (Harbin General Pharmaceutical Factory (150086)) |
| |
| Abstract: | Objective： To prepare the inclusion compound of indometacin - β-cyclodextrin （β-CD）and investigate its properties. Methods： The inclusion compound of indometacin β-CD was prepared by the co-precipetation method. Results： The inclusion compound of β-CD was confirmed by microsvope and IR, the content analysis of the inclusion compound showed that the molecular ratio of indometacin to β-CD was 1：1. Conclusion： indometacin-β-cyclodextrin （β-CD）was succeeded. The soluability and dissolution rate were increased. |
| |
| Keywords: | Indometacin β-cyclodextrin inclusion compound |
| 本文献已被 维普 万方数据 等数据库收录！ |
