奥玛株单抗在慢性鼻窦炎伴鼻息肉患者治疗中的应用

慢性鼻窦炎伴鼻息肉(CRSwNP)的炎症机制复杂，现有治疗方式对其病情控制欠佳。奥玛株单抗可通过与IgE受体结合降低患者的免疫级联反应，已有研究证明其对缓解CRSwNP合并哮喘患者的鼻部症状有良好的效果，但针对伴嗜酸性粒细胞增多、IgE水平高的难治性复发性CRSwNP治疗效果的探索还需要更多、更大规模的随机对照实验来证明。本文结合该背景对奥玛株单抗的作用机制以及在CRSwNP中的应用进行阐述，为CRSwNP的治疗提供参考。

Application of omalzumab in patients with chronic sinusitis with nasal polyp type

The inflammatory mechanism of chronic sinusitis with nasal polyp type (CRSwNP) is complex, and existing treatments are ineffective in controlling the disease. Omalizumab reduces the immune cascade by binding to IgE receptors in patients with CRSwNP. Omalizumab has been proved to be effective in alleviating nasal symptoms in patients with asthma complicated with CRSwNP. However, the efficacy of omalizumab in refractory relapsing CRSwNP with eosinophilia and high IgE levels needs to be demonstrated in more and larger randomized controlled trials. In this paper, the application and the mechanism of omalizumab in patients with CRSwNP with asthma, which was described in combination with this background, so as to provide reference for the treatment of CRSwNP.