| 银屑病与亚甲基四氢叶酸还原酶基因多态位点A677V关系的研究 |
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| 引用本文： | 杨维玲,王晓慧,郑淑云. 银屑病与亚甲基四氢叶酸还原酶基因多态位点A677V关系的研究[J]. 中华皮肤科杂志, 1999, 32(2): 87-88 |
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| 作者姓名： | 杨维玲 王晓慧 郑淑云 |
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| 作者单位： | 哈尔滨医科大学附属第一医院(杨维玲!150001,王晓慧!150001,郑淑云!150001),哈尔滨医科大学生物遗传学研究室(孙智晶,王柏秋,傅松滨) |
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| 摘 要： | 目的 探讨银屑病与亚甲基四氢叶酸还原酶基因多态位Ａ６７７Ｖ的关系。方法 采用聚合酶链反应－限制性片段长度多态性,检测了３个银屑病家系和３９例银屑病患者的亚甲基四氢叶酸还原酶基因多态位点Ａ６７７Ｖ,结果 银屑病患者亚甲基四氢叶酸还原酶不耐热缺陷与正常人有显著性差异。结论 亚甲基四氢叶酸还原酶Ａ６７７Ｖ突变型与银屑病发病相关。
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| 关 键 词： | 银屑病 四氢叶酸脱氢酶 PCR－RFLP |
Study on the Relationship Between Psoriasis and the Polymorphic Site A677V of Methylenetetrahydrofolate Reductase Gene |
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| YANG Weiling,WANG Xiaohui,ZHENG Shuyun,et al.. Study on the Relationship Between Psoriasis and the Polymorphic Site A677V of Methylenetetrahydrofolate Reductase Gene[J]. Chinese Journal of Dermatology, 1999, 32(2): 87-88 |
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| Authors: | YANG Weiling WANG Xiaohui ZHENG Shuyun et al. |
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| Affiliation: | YANG Weiling,WANG Xiaohui,ZHENG Shuyun,et al.Department of Dermatology,First Affiliated Hospital of Harbin Medical University,Harbin 150001 |
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| Abstract: | Objective To investigate the relationship between polymorphic site A667V of 5,10 methylenetetrahydrofolate reductase (MTHFR) gene and psoriasis . Methods PCR RFLP method was used to detect the polymorphism of MTHFR gene in 3 psoriasis pedigrees and 39 psoriatics . Results Genotype frequencies of the psoriastics were A/A 20.51%, A/V=48.72%and V/V=30.76%;the allelic frequencies were A=0.4487 and V=0.5513 . Conclusion There is a significant difference of MTHFR gene thermolabile defect between the psoriatics and the control, and our results demonstrate MTHFR gene is related to A667V mutant. |
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| Keywords: | Psoriasis Tetrahydrofolate dehydrogenase PCR RFLP |
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