| 整肠灵对脾胃虚寒型大鼠肠易激综合征的胃肠激素影响 |
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| 引用本文： | 李合国,虞坚尔. 整肠灵对脾胃虚寒型大鼠肠易激综合征的胃肠激素影响[J]. 河南大学学报(医学版), 2002, 21(3): 11-14 |
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| 作者姓名： | 李合国 虞坚尔 |
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| 作者单位： | 1. 河南大学一附院,消化内科,河南,开封,475001
2. 上海中医药大学,上海,200032 |
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| 摘 要： | 目的 :探讨整肠灵对脾胃虚寒型大鼠肠易激综合征的胃肠激素影响。方法 :选择 5 0只Wistar大鼠 (180±2 0g)随机分成五组 ,即正常组 (NG)、模型组 (MG)、大剂中药方组 (LG)、小剂中药方组 (SG)、得舒特组 (DG)。分别给予整肠灵 ,得舒特 ,生理盐水灌胃。观察体重、稀便级、碳末推进率、血浆和组织中的SS、VIP的含量变化。结果 :该方明显改善脾胃虚寒型IBS的大鼠症状体征 ,且成一定的量效关系 ,降低SS、VIP的含量。结论 :该方可通过调整紊乱的胃肠激素分泌、释放来达到治疗目的
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| 关 键 词： | 〗肠易激综合征 胃肠激素 生长抑素 血管活性肠肽 稀便级 |
| 文章编号： | 1008-2867(2002)03-0011-04 |
| 修稿时间： | 2002-07-25 |
Effects of Zhengchangling on gastrointestinal Hormone of Rats Irritable Bowel sgndrome with splenogastric Deficiency |
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| LI He-guo ,YU Jian-er. Effects of Zhengchangling on gastrointestinal Hormone of Rats Irritable Bowel sgndrome with splenogastric Deficiency[J]. Journal of Henan University, 2002, 21(3): 11-14 |
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| Authors: | LI He-guo YU Jian-er |
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| Affiliation: | LI He-guo 1,YU Jian-er 2 |
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| Abstract: | Objective: To study the effects of zhengchangling on rats Irritable Bowel Syndrome (IBS) with splenogastric deficiency Methods: Selected 50 wistar rats were divided randomly into 5 groups:normal group(NG),model group(MG),large-dose herb group(LG),small-dose herb group(SG) and Dicetel goup(DG) Five groups were perfused with physiological saline large-dose and small-dose zhengchangling and Dicetel individually Body weight,degree of diarrhea,charcoal suspension pushing rates and cencentration of SS?VIP in plasma and intestinal tissue were determined Results: The Fang can effectively improve bodyweight and diarrhea of rats On IBS with splenogastric deficiency and lower the increased concentration of SS and VIP Conclusion: Zhengchanglingshowed satisfactory therapeutic effects on IBS with splenogastric deficiency by means of adjusting the disordered secretion and release pattens of gastrointestinal hormones |
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| Keywords: | irritable bowel syndrome gastrointestinal hormone somatostatin(SS) vasoactive intestinal peptide (VIP) degree of diarrhea |
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