Alterations in the thyroids of rats treated for long periods with di-(2-ethylhexyl) phthalate or with hypolipidaemic agents |
| |
Authors: | S C Price D Chescoe P Grasso M Wright R H Hinton |
| |
Affiliation: | Robens Institute of Industrial and Environmental Health and Safety, University of Surrey, Guildford, U.K. |
| |
Abstract: | Treatment of rats for periods of 3 months or longer with the hypolipidaemic drugs clofibrate and fenofibrate or with the plasticiser di-(2-ethylhexyl) phthalate causes alterations in the thyroid. The colloid is shrunken and contains calcium-rich inclusions. Electron microscopy shows increases in the number and size of lysosomes, hypertrophy of the Golgi apparatus and dilation of the rough endoplasmic reticulum. These changes are consistent with persistent hyperactivity in the gland. |
| |
Keywords: | |
本文献已被 ScienceDirect 等数据库收录! |