辅酶Q10对老化模型小鼠大脑皮层抗氧化功能的影响

目的　研究辅酶Q10 对D 半乳糖衰老模型小鼠大脑皮层抗氧化功能的影响。　 方法 　小鼠随机分为正常对照组、衰老模型组、维生素E组、辅酶Q10 组。腹腔注射D 半乳糖建立衰老模型 ,为衰老模型小鼠分别补充维生素E、辅酶Q10 。 8周后测定大脑皮层中丙二醛 (MDA)、脂褐素含量、超氧化物歧化酶 (SOD)活性。　 结果 　与衰老模型组比较 ,辅酶Q10 组SOD活性升高 ,MDA和脂褐素含量下降。　 结论　辅酶Q10 能提高脑组织的抗氧化能力 ,其作用与维生素E差异无显著性。

Effects of coenzyme Q10 on the antioxidant ability of the cerebral cortex in induced senile mice

Objective To study the effects of coenzyme Q- 10 on the antioxidant ability of the cerebral cortex in D-galactose induced senile mice. Methods Mice were randomly divided into four groups:control group,D-galactose induced senile group,vitamin E group and coenzyme Q- 10 group.Senile model was established by injecting D-galactose in abdomen and senile mice were given vitamin E and coenzyme Q- 10 respectively.The contents of MDA and lipofuscin and the SOD activities were determined. Results Compared with D-galactose induced senile group,the MDA and lipofuscin contents were both decreased,and SOD activities were increased in coenzyme Q- 10 group(.P.<0.05). Conclusions Coenzyme Q- 10 could improve the antioxidant ability of brain and it has the same effect as vitamin E.