|
|||||
|
|
| 辅酶Q10对老化模型小鼠大脑皮层抗氧化功能的影响 | |
| 引用本文： | 王怀颖,张玮,刘和娣,石少慧,张秋燕.辅酶Q10对老化模型小鼠大脑皮层抗氧化功能的影响[J].实用老年医学,2004,18(4):201-202. |
| 作者姓名： | 王怀颖 张玮 刘和娣 石少慧 张秋燕 |
| 作者单位： | 1. 河北职工医学院生化教研室,保定市,071000 2. 保定市传染病医院检验科,071000 3. 河北医科大学生化教研室,石家庄,050000 |
| 摘 要： | 目的 研究辅酶Q10 对D 半乳糖衰老模型小鼠大脑皮层抗氧化功能的影响。 方法 小鼠随机分为正常对照组、衰老模型组、维生素E组、辅酶Q10 组。腹腔注射D 半乳糖建立衰老模型 ,为衰老模型小鼠分别补充维生素E、辅酶Q10 。 8周后测定大脑皮层中丙二醛 (MDA)、脂褐素含量、超氧化物歧化酶 (SOD)活性。 结果 与衰老模型组比较 ,辅酶Q10 组SOD活性升高 ,MDA和脂褐素含量下降。 结论 辅酶Q10 能提高脑组织的抗氧化能力 ,其作用与维生素E差异无显著性。 |
| 关 键 词： | 辅酶Q_(10) D半乳糖 衰老 小鼠 |
| 文章编号： | 1003-9198(2004)04-0201-02 |
| 修稿时间： | 2004年2月22日 |
Effects of coenzyme Q10 on the antioxidant ability of the cerebral cortex in induced senile mice |
|
| Wang Huaiying,Shi Shaohui,Zhang Qiuyan.Hebei Medical College for Continuing Education,Baoding ,Zhang Wei.Hospital for Infectious Diseases of Baoding,Baoding ,Liu Hedi.Hebei Medical University.Shi Jiazhang.Effects of coenzyme Q10 on the antioxidant ability of the cerebral cortex in induced senile mice[J].Practical Geriatrics,2004,18(4):201-202. | |
| Authors: | Wang Huaiying Shi Shaohui Zhang QiuyanHebei Medical College for Continuing Education Baoding Zhang WeiHospital for Infectious Diseases of Baoding Baoding Liu HediHebei Medical UniversityShi Jiazhang |
| Institution: | Wang Huaiying,Shi Shaohui,Zhang Qiuyan.Hebei Medical College for Continuing Education,Baoding 071000,Zhang Wei.Hospital for Infectious Diseases of Baoding,Baoding 071000,Liu Hedi.Hebei Medical University.Shi Jiazhang 050000 |
| Abstract: | Objective To study the effects of coenzyme Q- 10 on the antioxidant ability of the cerebral cortex in D-galactose induced senile mice. Methods Mice were randomly divided into four groups:control group,D-galactose induced senile group,vitamin E group and coenzyme Q- 10 group.Senile model was established by injecting D-galactose in abdomen and senile mice were given vitamin E and coenzyme Q- 10 respectively.The contents of MDA and lipofuscin and the SOD activities were determined. Results Compared with D-galactose induced senile group,the MDA and lipofuscin contents were both decreased,and SOD activities were increased in coenzyme Q- 10 group(.P.<0.05). Conclusions Coenzyme Q- 10 could improve the antioxidant ability of brain and it has the same effect as vitamin E. |
| Keywords: | Coenzyme Q- 10 D-galactose Aging Mice |
| 本文献已被 CNKI 维普 万方数据 等数据库收录！ | |