特殊导泻对急性百草枯中毒预后的影响

目的总结抢救急性百草枯中毒的临床经验。方法将2002年10月-2007年4月收治我院ICU的急性百草枯中毒患者69例分为2组：2002年10月-2005年7月收治的30例患者没有行特殊导泻治疗,作为对照组;2005年8月-2007年4月收治的39例患者为特殊组,在入院后即刻采用特殊导泄（思密达、硫酸镁、甘露醇）治疗。结果特殊组病死率明显低于对照组（69.2%vs90.0%,P〈0.05）;口服PQ后6h内收住ICU的患者中,特殊组的病死率亦低于对照组（22.2%vs83.3%,P〈0.025）,口服PQ6h后收住ICU的患者中,2组病死率无显著性差异。结论早期采用思密达、甘露醇、硫酸镁混合吸附导泻的方法可降低急性百草枯中毒的病死率,且安全、简单、易行。

Influence of Special Catharsis on Prognosis of Patients with Acute Toxicity of Paraquat

Objective To sum up the clinical experience of rescuing patients with acute toxicity of paraquat. Methods 69 cases with acute toxicity of paraquat from October 2002 to April 2007 were divided into two groups： the control group（ n = 30, from October 2002 to July 2005 ） underwent routine treatment, and the special group （n = 39, from August 2005 to April 2007 ） leaded to diarrhea by special treatment with smecta, magnesium sulfate and mannitol. Results In comparison to the control group, the mortality of the special group was significantly lower（69.2% vs 90.0% ,P 〈0.05 ） , and so for the cases accepted the ICU hospitalization within 6 hours after oral paraquat （22.2% vs 83.3% ,P 〈 0.05 ）. But there was no significant difference in the mortality of cases accepted the ICU hospitalization 6 hours later after oral paraquat. Conclusions The therapy of early leading to diarrhea by using smecta, magnesium sulfate and mannitol can reduce the mortality rate of patients with acute toxicity of paraquat,it was a simple and safe method.