肿瘤特异性生长因子与子宫内膜癌血管生成及转移的关系

目的:探讨血清肿瘤特异性生长因子(TSGF)检测与子宫内膜癌血管生成、浸润转移的关系。方法:采集33例子宫内膜癌患者静脉血,采用化学比色法、ELISA检测血清TSGF、血管内皮生长因子(VEGF)、基质金属蛋白酶2(MMP-2)及基质金属蛋白酶9(MMP-9)的含量,并与子宫肌瘤患者及正常妇女比较。结果:子宫内膜癌患者血清TSGF、MMP-2及MMP-9含量均明显高于子宫肌瘤患者,差异有统计学意义(P<0.05),VEGF略有升高,但无显著差异(P>0.05);与正常妇女相比,水平均明显升高(P<0.05)。子宫肌瘤患者血清TSGF、VEGF、MMP-2及MMP-9与正常妇女相比无显著差异(P>0.05)。结论:与VEGF相比,TSGF可特异性地刺激恶性肿瘤的血管生成,TSGF、MMP-2及MMP-9在肿瘤的浸润转移中发挥重要作用。

Relationship between Serum TSGF and Tumor Angiogensis, Invasion, Metastasis in Endometrium Carcinoma

Objective:To study the relationship between serum tumor specific growth factor(TSGF)level and tumor angiogen- sis,invasion,metastasis in endometrium carcinoma.Methods:We collected the blood of the patients with carcinoma of endome trium,and examined the level of TSGF,vascular endothelial growth factor(VEGF),matrix metalloproteinase-2(MMP-2)and matrix metalloproteinase-9(MMP-9).then compared with hysteromyoma patients and healthy controls.Results:Statistical sig nificance of the levels of TSGF VEGF,MMP-2 and MMP-9 were found when endometrium cancer group was compared with control group(P<0.05).Compared with the patients ofhysteromyoma,the levels of TSGF,MMP-2 and MMP-9 were great- ly higher(P<0.05),but there was no significant difference in the level of VEGF(P>0.05).The levels of TSGF.MMP-2 and MMP-9 were similar between the hysteromyoma and normal group(P>0.05).Conclusion:Serum TSGF associated with MMP-2 and MMP-9 may work on tumor invasion and metastasis.It advance tumur angiogenesis as VEGF.and play a more im- portant role.