~(103)Pd radioactive stent inhibits biliary duct restenosis and reduces smooth muscle actin expression during duct healing in dogs

Introduction In recent years, the metal internal stent is widely used in benign or malignant stenosis of the esophagus, bronchus, biliary duct and blood vessels.[1, 2] Especially in the biliary stenosis caused by benign or malignant biliary disease, the internalstent not only resolves the stenosis, but also provides the conditions for further treatment, such as by radiotherapy.[3, 4] However, the 7%-42% restenosis rate limits the clinical use of the metal internal stent.[5] Treatment of biliar…

~(103)Pd radioactive stent inhibits biliary duct restenosis and reduces smooth muscle actin expression during duct healing in dogs

BACKGROUND: This study was designed to assess the expression of smooth muscle actin (SMA) in the healing process after implanting a 103Pd radioactive stent in the biliary duct, and to discuss the function and significance of this stent in preventing biliary stricture formation. METHODS: A model of biliary injury in dogs was made and then a 103Pd radioactive stent was positioned in the biliary duct. The expression and distribution of SMA were assessed in the anastomotic tissue 30 days after implantation of the stent. RESULTS: SMA expression was less in the 103Pd stent group than in the ordinary stent group. The 103Pd stent inhibited scar contracture and anastomotic stenosis. CONCLUSION: The 103Pd stent can reduce the expression of SMA in the healing process and inhibit scar contracture and anastomotic stenosis in the dog biliary duct.