女性不孕不育血清相关自身抗体检测的分析

目的:探讨自身抗体检测对女性不孕不育诊断的意义。方法:采用化学发光法测定149例原发性不孕、466例继发性不孕、320例习惯性流产及45例正常生育妇女血清抗精子抗体(AsAb)、抗子宫内膜抗体(EmAb)、抗心磷脂抗体(ACA)水平。结果:原发性不孕组中,AsAb阳性率为26.17%,EmAb阳性率为17.45%,ACA阳性率为12.75%;继发性不孕组中,AsAb阳性率为28.97%,EmAb阳性率为20.17%,ACA阳性率为19.10%;习惯性流产组中,AsAb阳性率为19.06%,EmAb阳性率为9.06%,ACA阳性率为28.12%;对照组中,AsAb和ACA阳性率为2.22%,EmAb为0%。不孕不育各组的阳性检出率均高于对照组,差异有统计学意义(χ2=33.02,P<0.05)。结论:血清相关自身抗体检测对女性免疫性不孕不育的诊断有重要意义。

Analysis of female infertility related serum autoantibodies detection

Objective： To investigate the diagnostic significance of female infertility related autoantibody detection. Methods： Chemiluminescent method was applied to detect levels of antisperm anti- body（AsAb）, endometrial antibody （EmAb）, anticardiolipin antibody （ACA） in 149 cases of primary in- fertility, 466 cases of secondary infertility, 320 cases of habitual abortion and 45 cases of normal reproduc- tive women. Results： The positive rate of AsAb,EmAb,and ACA was 26.17%, 17.45%, and 12.75% in the primary infertility group, 28.97%, 20.17%, 19.10% in the secondary infertility group, and 19.06%, 9.06%, 28.12% in the habitual abortion group, while in the normal control group, the positive rate of AsAb, ACA and EmAb were 2.22 %, 2.22% and 0. Postive rate of AsAb, ACA and EmAb of infertility group were all significant higher than that of the control （x2 =33.02,P〈0.05）. Conclusion： The detection of serum autoantibodies associated with the female immune infertility is informative for diagnosis.