| 齐拉西酮对难治性抑郁症的增效作用研究 |
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| 引用本文： | 董莹盈,冯虹,童伟隆.齐拉西酮对难治性抑郁症的增效作用研究[J].药物流行病学杂志,2011(11):565-567. |
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| 作者姓名： | 董莹盈 冯虹 童伟隆 |
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| 作者单位： | 绍兴市第七人民医院心理科（浙江绍兴 312000）;绍兴市第七人民医院心理科（浙江绍兴 312000）;绍兴市第七人民医院心理科（浙江绍兴 312000） |
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| 摘 要： | 目的：观察齐拉西酮对难治性抑郁症的增效作用及其安全性。方法：67例难治性抑郁症患者随机分为观察组（文拉法辛联合齐拉西酮）32例，对照组（单用文拉法辛）35例。疗程8周，于治疗前及治疗后1、2、4、8周分别用汉密尔抑郁量表（HAMD）及临床总体印象量表（CGI）评定疗效，不良反应量表（TESS）评定不良反应及安全性。结果：两组治疗后HAMD、CGI评分均较治疗前显著下降（P〈0．05或0．01），而合用组起效时间迅速，两组不良反应相仿。结论：增效剂治疗难治性抑郁症安全有效。
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| 关 键 词： | 齐拉西酮 难治性抑郁症 增效剂 |
| 收稿时间： | 2011/6/22 0:00:00 |
| 修稿时间： | 2011/8/24 0:00:00 |
Study of the Synergy of Ziprasidone in the Treatment of Refractory Depression |
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| Dong Yingying,Feng Hong and Tong Weilong.Study of the Synergy of Ziprasidone in the Treatment of Refractory Depression[J].Chinese Journal of Pharmacoepidemiology,2011(11):565-567. |
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| Authors: | Dong Yingying Feng Hong and Tong Weilong |
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| Institution: | Dong Yingying,Feng Hong,Tong Weilong Department of Psychology,7th Hospital of Shaoxing City,Shaoxing 312000,Zhejiang,China |
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| Abstract: | Objective:To observe the synergy and safety of ziprasidone in the treatment of refractory depression. Method;67 refractory depression patients were randomly divided into the combined group(venlafaxin combined with ziprasidone) and the controlled group(venlafaxin only) for their treatment for 8 weeks.The efficacy and adverse drug reaction were evaluated with HAMD,CGI and TESS at the end of the 1~(st),2~(nd),4~(th) and 8~(th) weeks.Result:The scores of HAMD and CGI were significantly reduced after every treat... |
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| Keywords: | Ziprasidone Refractory depression Synergist |
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