S100A4蛋白在乳腺癌组织的表达及临床意义

目的：探讨S100A4蛋白在乳腺癌组织的表达、相关性及临床意义。方法：采用免疫组织化学SP法检测55例乳腺癌组织和16例乳腺良性病变中S100A4蛋白的表达。结果：S100A4在乳腺癌组织中阳性率55．45％显著高于良性病变组织（P〈0．05），S100A4在腋淋巴结阳性组和复发／远处转移组的阳性表达率明显高于腋淋巴结阴性组和无复发、转移组（P〈0．05）；生存期≥5年组S100A4阳性率明显低于生存期〈5年组（P〈0．05）；与生存期呈负相关。S100A4蛋白与乳腺癌患者年龄、肿块大小、病理学分类、临床分期、ER、PR表达状态及月经状况无关（P〉0．05）。结论：乳腺癌组织S100A4蛋白表达增高与肿瘤的发生发展及预后密切相关，是判断乳腺癌生物学行为、预测转移趋势的有价值的参考指标，并有可能成为乳腺癌基因治疗的新靶点。

Expression of S100A4 in breast cancer and the significance

Objective：To investigate the expression of S100A4 gene in human breast cancer and evaluate its clinical significance. Methods： The expression of S100A4 protein was investigated by means of immunohistochemistry in 55 cases of breast cancer and 16 cases of breast benign diseases. The relation of S100A4 expression to clinicopathological characteristics and postoperative survival time was statistically analyzed. Results ： The expression of S100A4 was significantly different between breast cancer and benign diseases （ P 〈 0.05 ）. The positive rates of S100A4 expression in the axillary lymph nodes metastasis, multiple lymph nodes metastasis （ ≥4 nodes ） and postoperative local recurrence or distant metastasis group were obviously higher than corresponding control groups （ P 〈 0.05 ）. The positive rates of S100A4 expression in survival time≥5 years group were lower than those in patients survival time 〈 5 years group （P 〈 0.05 ）. Expression of S100A4 had no relation with age of patients, tumor size, tumor pathological type, the clinical TNM stage, ER, PR expression and menses status （P 〉0.05）. Conclusion： The increase of S100A4 protein expression is significantly associated with tumor progression in breast cancer , and it may be considered as a valuable marker for predicting the biological behavior and metastasis for breast cancer.