| 尿道下裂患儿包皮组织中表皮生长因子 |
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| 引用本文： | 袁继炎,周学锋,王军.尿道下裂患儿包皮组织中表皮生长因子[J].中华小儿外科杂志,2001,22(1):30-31. |
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| 作者姓名： | 袁继炎 周学锋 王军 |
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| 作者单位： | 1. 同济医科大学附属同济医院小儿外科
2. 武汉市儿童医院外科, |
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| 摘 要： | 目的 探讨表皮生长因子（EGF）及其表皮生长因子受体（EGFR）在尿道下裂发生中的作用。方法 应用免疫组织化学染色方法对15例尿道下裂患儿包皮组织和尿道板中EGF、EGFR表达进行检测。结果 15例尿道下裂患儿包皮组织中EGF、EGFR阳性细胞指数分别为195±4、153±8,均低于正常儿童为212±4，225±6（P<0.01），尿道板中EGF、EGFR阳性细胞指数分别为153±8、118±7,亦明显少于其包皮组织（P<0.01）。结论 EGF、EGFR在包皮组织中的不足表达和不均衡分布可能与尿道下裂的发生有关。
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| 关 键 词： | 尿道下裂 表皮生长因子 表皮生长因子受体 儿童 包皮组织 |
| 修稿时间： | 1999年9月7日 |
Expression of epidermal growth factor （EGF）and EGF receptor in hypospadias |
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| WANG Jun,YUAN Jiyan,ZHOU Xuefeng.Expression of epidermal growth factor （EGF）and EGF receptor in hypospadias[J].Chinese Journal of Pediatric Surgery,2001,22(1):30-31. |
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| Authors: | WANG Jun YUAN Jiyan ZHOU Xuefeng |
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| Institution: | WANG Jun,YUAN Jiyan,ZHOU Xuefeng. Department of Pediatric Surgery,Tongji Hospital,Tongji Medical University,Wuhan 430030,China |
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| Abstract: | Objective To investigate the expression of epidermal growth factor(EGF)and EGF receptor(EGFR) in children with hypospadias.Methods The expression of EGF and EGFR was detected in the prepuce tissue from 15 boys with hypospadias using immunohistochemical technique.Results The positive expression of EGF and EGFR in the prepuces from hypospadias was much less than that in normal children.The positive expression of EGF and EGFR in the urethra plate of hypospadias were much less than that in the prepuce.Conclusion The inadequate expression and unproportional distribution of EGF and EGFR may be related to the incidence of hypospadias. |
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| Keywords: | Hypospadias Epidermal Growth Factor Epidermal growth factor receptor |
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