| 头孢吡肟致神经毒性文献分析 |
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| 引用本文： | 白东玉,刘颖,崔向丽,魏锦绣.头孢吡肟致神经毒性文献分析[J].药物流行病学杂志,2010(3):144-146. |
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| 作者姓名： | 白东玉 刘颖 崔向丽 魏锦绣 |
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| 作者单位： | 秦皇岛海港医院药剂科;北京天坛医院药剂科;新疆奎屯市中心医院药剂科; |
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| 摘 要： | 目的：对头孢吡肟引起神经毒性的国内外文献进行统计分析，提示临床应用注意本药可导致神经毒性，避免引起严重后果。方法：利用中国期刊网数据库和Pubmed检索1999—2009年报道静滴头孢吡肟引起神经毒性不良反应的文献，分析其引起神经毒性的规律和特点。结果：共检索到头孢吡肟引起神经毒性的文献71篇，中文文献53篇，英文文献18篇。其中个例报道36例。头孢吡肟引起神经毒性发病年龄平均为64．5岁，1例高龄患者死亡，死亡率为2．8％。结论：头孢吡肟引起神经毒性与患者年龄和肾功能密切相关，与患者性别、给药剂量无明显相关性。
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| 关 键 词： | 头孢吡肟 β-内酰胺类药 神经毒性 文献分析 |
Analysis of Neurotoxicity Caused by Cefepime |
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| Bai Dongyu,Liu Ying,Cui Xiangli,Wei Jinxiu .Pharmacy.Analysis of Neurotoxicity Caused by Cefepime[J].Chinese Journal of Pharmacoepidemiology,2010(3):144-146. |
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| Authors: | Bai Dongyu Liu Ying Cui Xiangli Wei Jinxiu Pharmacy |
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| Institution: | Bai Dongyu~(1,2),Liu Ying~1,Cui Xiangli~2,Wei Jinxiu~3 1.Pharmacy Department of Qinhuangdao Hospital,Qinhuangdao 066000,Hebei China,2.Pharmacy Department of Beijing Tiantan Hospital Affiliated to Capital Medical University,3.Parmacy Department of Xinjiang Kuitun District Hospital |
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| Abstract: | Objective:To analyze domestic and foreign literatures which carried the reports of neurotoxicity induced by cefepime in order to warn the clinic to pay attention to its possible neurotoxicity and to avoid the occurrence of its serious adverse drug effects.Method:The literatures were searched for on www.cnki.net and PUBMED which reported the neurotoxicity induced by cefepime from 1999 to 2009 and the rules and characteristics of neurotoxicity induced by cefepime were analyzed.Result:71 articles including 53 ... |
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| Keywords: | Cefepime β-lactam antibiotic Neurotoxicity Literature analysis |
| 本文献已被 CNKI 维普 等数据库收录！ |
