| 4817例HLA-B27检测对SpA和非SpA诊断价值的分析 |
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| 引用本文： | 魏秋静,李秋霞,李齐光. 4817例HLA-B27检测对SpA和非SpA诊断价值的分析[J]. 新医学, 2011, 42(3): 160-161,169. DOI: 10.3969/g.issn.0253-9802.2011.03.007 |
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| 作者姓名： | 魏秋静 李秋霞 李齐光 |
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| 作者单位： | 中山大学附属第三医院风湿科,510630 |
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| 摘 要： | 目的：探讨HIA-B27对腰背痛疑诊或待排除，SpA患者的鉴别诊断价值。方法：采用补体依赖淋巴细胞毒试验（CDC）检测4414例以腰背痛就诊的患者及403名健康对照者的HLA-B27，结合患者临床资料分析HLA．B27在不同性别和疾病（SpA和非SpA两组）中的阳性分布情况。结果：4414例腰背痛疑诊或待排除SpA人群HLA-B27的阳性率为49．81％，男女HLA．B27阳性率比较差异无统计学意义（P〉0．05）；在SpA组AS、未分化型SpA（USpA）、幼年SpA（JSpA）、反应性关节炎（ReA）和银屑病关节炎（PsA）HLA—B27阳性率分别为90．07％、28．85％、68．81％、52．94％和67．74％。非SpA组HLA．B27阳性率为19．33％，与健康对照组比较差异有统计学意义（P〈0．05）。结论：非SpA患者HLA．B27也可能阳性，HLA-B27检测阳性不能单纯考虑SpA。
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| 关 键 词： | 脊柱关节病 强直性脊柱炎 人类白细胞抗原B27 补体依赖的淋巴细胞毒试验 |
Analysis of the diagnostic significance of HLA-B27 in spondyloarthropathy and non-spondyloarthropathy: report of 4 817 cases |
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| WEI Qiu-jing,LI Qiu-xia,LI Qi-guang. Analysis of the diagnostic significance of HLA-B27 in spondyloarthropathy and non-spondyloarthropathy: report of 4 817 cases[J]. New Chinese Medicine, 2011, 42(3): 160-161,169. DOI: 10.3969/g.issn.0253-9802.2011.03.007 |
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| Authors: | WEI Qiu-jing LI Qiu-xia LI Qi-guang |
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| Affiliation: | WEI Qiu-jing,LI Qiu-xia,LI Qi-guang.Department of Rheumatology,The Third Affiliated Hospital of SUN Yat-sen University,Guangzhou 510630,China |
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| Abstract: | Objective:To study the application of HLA-B27 antigen detection in diagnosis of spondyloarthropathy(SpAs) in patients with low back pain.Methods:HLA-B27 antigen detection with complement-dependent lymphocytotoxicity was performed in 4 414 patients who sought medical consultation with low back pain and 403 healthy controls.Analysis of HLA-B27 positive distributions in different gender and diseases(SpA and have non-SpA)was performed.Results:The positive rate of HLA-B27 antigen was 49.81% in 4 414 patients wit... |
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| Keywords: | Spondyloarthropathy Ankylosing spondylitis Human leucocyte antigen B27 Complement-dependent lymphocytotoxicity method |
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