| TLR-2、TLR-4在强直性脊柱炎患者外周血单个核细胞中的表达及其临床意义 |
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| 引用本文： | 毋静,于清宏,曲源,廖泽涛,魏秋静,古洁若. TLR-2、TLR-4在强直性脊柱炎患者外周血单个核细胞中的表达及其临床意义[J]. 新医学, 2011, 42(3): 166-169. DOI: 10.3969/g.issn.0253-9802.2011.03.009 |
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| 作者姓名： | 毋静 于清宏 曲源 廖泽涛 魏秋静 古洁若 |
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| 作者单位： | 1. 南方医科大学珠江医院风湿免疫科,510280
2. 中山大学附属第三医院风湿科,510630 |
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| 摘 要： | 目的：探讨TLR-2和TLR-4在AS患者PBMC中的表达及其临床意义。方法：选择AS患者及健康志愿者各30例，分为AS组和健康对照组。采用RT-PCR及蛋白免疫印迹技术检测两组受检者PBMC中TLR-2和TLR-4的表达水平。结果：As组TLR-2mRNA、TLR4mRNA表达水平分别为1．59±1．43、0．60±0．73，均高于健康对照组的0．06±0．04、0．06±0．39（JP均〈0．05）。AS组TLR-4蛋白表达水平为12．0±8．6，高于健康对照组的4．5±2．1（P〈0．05）。AS患者的BASDAI、BASFI与TLR-2mRNA表达水平呈正相关（r分别为0．759、0．664，P〈0．01）；AS患者的BASDAI与TLR-4mRNA表达水平呈正相关（r=0．347，P〈0．01）。结论：AS患者TLR-2、和TLR-4的表达水平高于健康志愿者，并与其自身疾病活动性存在一定程度的相关性，TLR-4或许可以作为评估AS病情活动的有价值的参考指标。
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| 关 键 词： | 强直性脊柱炎 Toll样受体 Bath强直性脊柱炎疾病活动指数 Bath强直性脊柱炎功能指数 |
Expression and significance of toll like receptor 2 and toll like receptor 4 in the peripheral blood mononuclear cells in patients with ankylosing spondylitis |
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| WU jing,YU Qing-hong,QU Yuan,LIAO Ze-tao,WEI Qiu-jing,GU Jie-ruo. Expression and significance of toll like receptor 2 and toll like receptor 4 in the peripheral blood mononuclear cells in patients with ankylosing spondylitis[J]. New Chinese Medicine, 2011, 42(3): 166-169. DOI: 10.3969/g.issn.0253-9802.2011.03.009 |
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| Authors: | WU jing YU Qing-hong QU Yuan LIAO Ze-tao WEI Qiu-jing GU Jie-ruo |
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| Affiliation: | WU jing1,YU Qing-hong1,QU Yuan1,LIAO Ze-tao2,WEI Qiu-jing2,GU Jie-ruo2.1 Department of Rheumatology,The Zhujiang Hospital of South Medical University,Guangzhou 510280,China,2 Department of Rheumatology,The Third Affiliated Hospital of SUN Yat-sen University,Guangzhou 510630 |
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| Abstract: | Objective:To explore the expression and significance of toll like receptor 2(TLR-2) and toll like receptor 4(TLR-4) in peripheral blood mononuclear cells(PBMC)in patients with ankylosing spondylitis(AS).Methods:Thirty patients with AS and 30 healthy volunteers were enrolled and assigned into AS group and control group,respectively.The expression of TLR-2 and TLR-4 in PBMC were determined by RT-PCR and western blot.Results:Significantly higher expression of TLR-2 mRNA,TLR-4 mRNA and TLR-4 protein was reveale... |
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| Keywords: | Ankylosing spondylitis Toll like receptors BASDAI BASFI |
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